S1384
N-Succinyl-Ala-Ala-Val p-nitroanilide
elastase substrate
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About This Item
Empirical Formula (Hill Notation):
C21H29N5O8
CAS Number:
Molecular Weight:
479.48
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
Pricing and availability is not currently available.
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Assay
≥98% (TLC)
form
powder
solubility
1 N NH4OH: 50 mg/mL, clear, yellow
storage temp.
2-8°C
SMILES string
CC(C)C(NC(=O)C(C)NC(=O)C(C)NC(=O)CCC(O)=O)C(=O)Nc1ccc(cc1)N(=O)=O
InChI
1S/C21H29N5O8/c1-11(2)18(21(32)24-14-5-7-15(8-6-14)26(33)34)25-20(31)13(4)23-19(30)12(3)22-16(27)9-10-17(28)29/h5-8,11-13,18H,9-10H2,1-4H3,(H,22,27)(H,23,30)(H,24,32)(H,25,31)(H,28,29)
InChI key
IFAOJWCXOQHSQT-UHFFFAOYSA-N
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Substrates
Substrate for human and rat leukocyte elastases
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Rami A Al-Horani et al.
Molecules (Basel, Switzerland), 24(11) (2019-06-09)
Pentamidine is bis-oxybenzamidine-based antiprotozoal drug. The parenteral use of pentamidine appears to affect the processes of blood coagulation and/or fibrinolysis resulting in rare but potentially life-threatening blood clot formation. Pentamidine was also found to cause disseminated intravascular coagulation syndrome. To
H R Wenzel et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 361(9), 1413-1416 (1980-09-01)
A simple synthesis is described for 3-carboxypropionyl-Ala-Ala-Val-4-nitroanilide, a convenient and very specific substrate for human leukocyte elastase (Km = 1.0mM, kcat = 8.7 s-1). The substrate does not undergo appreciable spontaneous hydrolysis. It is not cleaved by trypsin or chymotrypsin
G D Virca et al.
European journal of biochemistry, 144(1), 1-9 (1984-10-01)
Rat is a likely test animal for determining the efficacy of proteinase inhibitor drugs directed toward human leukocyte elastase and cathepsin G. We therefore sought to assess and compare relevant properties of both human and rat leukocyte elastase and cathepsin
Stein, R.L.,
Journal of the American Chemical Society, 105, 5111-5111 (1983)
Apparao B Kummarapurugu et al.
American journal of respiratory cell and molecular biology, 64(2), 260-267 (2020-12-03)
Cystic fibrosis (CF) lung disease is marked by high concentrations of neutrophil elastase (NE) and DNA polymers; both factors contribute to airway disease. Although inhaled recombinant human dornase alfa reduces the frequency of CF pulmonary exacerbations, it also increases free
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