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O5501

Sigma-Aldrich

Oxyphenonium bromide

Synonym(s):

2-([Cyclohexylhydroxyphenylacetyl]oxy)-N,N-diethyl-N-methylethanaminium bromide

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About This Item

Linear Formula:
C21H34NO3Br
CAS Number:
50-10-2
Molecular Weight:
428.40
EC Number:
200-010-7
MDL number:
MFCD00050259
UNSPSC Code:
12161900
PubChem Substance ID:
24898019

description

cationic

Assay

>98% (TLC)

mol wt

428.40 g/mol

SMILES string

Br.CC[N](C)(CC)CCOC(=O)C(O)(C1CCCCC1)c2ccccc2

InChI

1S/C21H34NO3.BrH/c1-4-22(3,5-2)16-17-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6,8-9,12-13,19,24H,4-5,7,10-11,14-17H2,1-3H3;1H

InChI key

JKJFWDDPBNHJPV-UHFFFAOYSA-N

Application

Oxyphenonium bromide has been used in a study to assess masking mechanisms of bitter taste of drugs. It has also been used in a study to investigate stoichiometric and microenvironmental effects on hydrolysis of propantheline in cyclodextrin solutions.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
044F0691

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G I Nezhinskaya et al.
Bulletin of experimental biology and medicine, 146(6), 747-749 (2009-06-11)
Antimuscarinic effects of ipratropium bromide and atropine are associated with prevention of the development of Arthus reaction, while the cytostatic effects of cyclophosphamide and doxorubicin lead to involution of the thymus and spleen, suppression of antibody production, and aggravation of
Marian Turcani et al.
Scientific reports, 9(1), 2586-2586 (2019-02-24)
Successful adaptation to passive hyperthermia requires continual adjustment of circulation, which is mediated mainly by the autonomic nervous system. The goal of this study was to explore the alterations in spontaneous cardiovagal baroreflex sensitivity (BRS) during exposure to a hot
Alaa El-Gindy et al.
Journal of AOAC International, 90(5), 1250-1257 (2007-10-25)
A high-performance liquid chromatographic (HPLC) method was developed for determination of oxyphenonium bromide (OX) and its degradation product. The method was based on the HPLC separation of OX from its degradation product, using a cyanopropyl column at ambient temperature with
Noriaki Funasaki et al.
Chemical & pharmaceutical bulletin, 54(8), 1155-1161 (2006-08-02)
The masking mechanisms of the bitter taste of propantheline bromide (PB) and oxyphenonium (OB) bromide by native and modified cyclodextrins, saccharides, surfactants, organic acids, nonionic and anionic polymers, and other compounds were investigated with ion selective electrodes. The intensity of
N Funasaki et al.
Journal of pharmaceutical sciences, 90(6), 740-748 (2001-05-18)
The effects of alpha-, beta-, and gamma-cyclodextrins (CDs) on the basic hydrolysis of propantheline bromide (PB) and oxyphenonium bromide (OB) are analyzed in terms of the stoichiometry and microenvironments of their complexes. The rate constant of each species is evaluated
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