M108

(−)-MK-801 hydrogen maleate

≥98% (HPLC)

• Synonym(s): (5R,10S)-(–)-5-Methyl-10,11-dihydro-5H-dibenzo­[a,d]­cyclo­hepten-5,10-imine hydrogen maleate
• Empirical Formula (Hill Notation): C₁₆H₁₅N · C₄H₄O₄
• CAS Number: 77086-19-2
• Molecular Weight: 337.37
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277961
• MDL number: MFCD00082466
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• optical activity: [α]25/D −117.7°, c = 1 in methanol(lit.)
• color: white
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: [H]\C(=C(/[H])C(O)=O)C(O)=O.[H][C@@]12Cc3ccccc3[C@@](C)(N1)c4ccccc24
• InChI: 1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1
• InChI key: QLTXKCWMEZIHBJ-FWHYOZOBSA-N
• Gene Information: human ... GRIN1(2902), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907) ; mouse ... GRIN1(14810), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168) ; rat ... GRIN1(24408), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

Description

General description

(-)-MK-801 hydrogen maleate is a less potent stereoisomer of (+)-MK-801.

Biochem/physiol Actions

Less active enantiomer of (+)-MK-801 hydrogen maleate

MK-801 functions as a selective non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)