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K-252a

Name: K-252a
Brand: SIGMA
Price: 1172 ILS

From Nonomuraea longicatena, >98%, tyrosine kinase receptor inhibitor, solution

Synonym(s):

SF 2370

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Size/SKU	Availability	Price
200 μL	Please contact Customer Service for Availability	₪1,172.00

About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₁N₃O₅

CAS Number:

99533-80-9

Molecular Weight:

467.47

NACRES:

NA.77

PubChem Substance ID:

329817131

UNSPSC Code:

12352200

EC Number:

200-664-3

MDL number:

MFCD00161522

Assay:

>98%

Form:

solution

₪1,172.00

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Properties

Product Name

K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%

biological source

Nonomuraea longicatena

Quality Segment

200

assay

>98%

form

solution

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key

KOZFSFOOLUUIGY-SOLYNIJKSA-N

Gene Information

human ... NTRK1(4914)
rat ... Prkca(24680)

Description

Biochem/physiol Actions

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Features and Benefits

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Physical form

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

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1 of 1

This Item	SAB1410624	CB_89070101	SCC127M
Sigma-Aldrich K2015 K-252a	Sigma-Aldrich SAB1410624 Anti-HGF antibody produced in rabbit	Sf9 Cell Line from Spodoptera frugiperda pupal ovarian tissue	Sigma-Aldrich SCC127M SF8628 Human DIPG H3.3-K27M Cell Line
description Ready Made Solution, from Nonomuraea longicatena, >98%	description purified immunoglobulin, buffered aqueous solution	description NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 89070101, insect ovary, Spherical	description SF8628 pediatric diffuse intrinsic pontine glioma (DIPG) cell line harbors the histone H3.3 Lys 27-to-methionine (K27M) mutation and can support research and drug development efforts targeting DIPG.
assay >98%	assay -	assay -	assay -
form solution	form buffered aqueous solution	form -	form -
Quality Level 200	Quality Level 100	Quality Level -	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −196°C	storage temp. -
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in -
Gene Information human ... NTRK1(4914) rat ... Prkca(24680)	Gene Information human ... HGF(3082)	Gene Information -	Gene Information -

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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K-252a

From Nonomuraea longicatena, >98%, tyrosine kinase receptor inhibitor, solution

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About This Item

₪1,172.00

Product Name

biological source

Quality Segment

assay

form

shipped in

storage temp.

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Features and Benefits

Physical form

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flash_point_f

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ppe

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K-252a

From Nonomuraea longicatena, >98%, tyrosine kinase receptor inhibitor, solution

Select a Size

About This Item

K2015-200UL

₪1,172.00

Product Name

biological source

Quality Segment

assay

form

shipped in

storage temp.

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Features and Benefits

Physical form

Compare Similar Items

This Item

Still not finding the right product?

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

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