GW22849
Anti-SLC12A2 (ab2) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Solute carrier family 12 member 2
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About This Item
UNSPSC Code:
12352203
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
manufacturer/tradename
Genway 15-288-22849
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... SLC12A2(6558)
Immunogen
Immunogen Sequence: GI # 4506975, sequence 114-285
Recombinant solute carrier family 12 (sodium/potassium/chloride transporters), member 2
Application
Anti-SLC12A2 (ab2) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
The Na-K-Cl cotransporter (NKCC) is a protein that helps in the active transport of sodium, potassium, and chloride into and out of cells. It couples the movement of Na+, K+ and Cl- ions across the plasma membrane of most animal cells and plays a central role in cellular homeostasis and human physiology. The proteins play important roles in Na+ and K+ concentrations in key physiological systems, including cardiac, vascular, renal, nervous and sensory systems. NKCC1 levels and functionality are altered in certain disease states. NKCC1 may play a role in glioma cell migration, the precise mechanism by which ion transporter contributes to Glioblastoma (GB) aggressiveness. Its expression levels are found to be significantly higher in GB and anaplastic astrocytoma tissues than in grade II glioma and normal cortex. It also plays a central role in cellular chloride homeostasis and in epithelial salt transport.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Suma Somasekharan et al.
PloS one, 8(12), e82060-e82060 (2013-12-18)
The Na-K-Cl cotransporter (NKCC) couples the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane of most animal cells and thus plays a central role in cellular homeostasis and human physiology. In order to study the structure, function
Suma Somasekharan et al.
The Journal of biological chemistry, 287(21), 17308-17317 (2012-03-23)
The Na-K-Cl cotransporter (NKCC) plays central roles in cellular chloride homeostasis and in epithelial salt transport, but to date little is known about the mechanism by which the transporter moves ions across the membrane. We examined the functional role of
Bo Ding et al.
American journal of physiology. Cell physiology, 306(1), C66-C75 (2013-11-01)
Sodium/potassium/chloride cotransporter (NKCC1) proteins play important roles in Na(+) and K(+) concentrations in key physiological systems, including cardiac, vascular, renal, nervous, and sensory systems. NKCC1 levels and functionality are altered in certain disease states, and tend to decline with age.
Tomas Garzon-Muvdi et al.
PLoS biology, 10(5), e1001320-e1001320 (2012-05-10)
Glioblastoma (GB) is a highly invasive and lethal brain tumor due to its universal recurrence. Although it has been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) can play a role in glioma cell migration, the precise mechanism by which
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