Skip to Content
Merck
All Photos(5)

Key Documents

View All Documentation

G8634

Sigma-Aldrich

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

≥90% (contains < 10% GDP, HPLC), powder

Synonym(s):

GTPγS tetralithium salt, GTP-γ-S-Li4, Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

Sign Into View Organizational & Contract Pricing

Select a Size

1 MG
₪563.00
10 MG
₪1,729.00
5 MG
₪1,937.00
25 MG
₪4,190.00

₪563.00

Please contact Customer Service for Availability
Request a Bulk Order
All Photos(5)

Select a Size

Change View
1 MG
₪563.00
10 MG
₪1,729.00
5 MG
₪1,937.00
25 MG
₪4,190.00

About This Item

Empirical Formula (Hill Notation):
C10H12Li4N5O13P3S
CAS Number:
94825-44-2
Molecular Weight:
562.98
Beilstein:
8182249
EC Number:
305-606-1
MDL number:
MFCD00135151
UNSPSC Code:
41106305
PubChem Substance ID:
24895344
NACRES:
NA.77

₪563.00

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

200

Assay

≥90% (contains < 10% GDP, HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

AMQXJFWJOAWCPV-ZVQJTLEUSA-J

Looking for similar products? Visit Product Comparison Guide

Application

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
  • as a component of lysis buffer[1]
  • in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state[2]
  • to couple with G- protein α, to study its effect on kinase activity[3]

Biochem/physiol Actions

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000387141
0000376016
0000376018
0000376017
0000340487

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Rab27a is an essential component of melanosome receptor for myosin Va
Wu X, et al.
Molecular Biology of the Cell, 13(5), 1735-1749 (2002)
Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway
Sanchez BP, et al.
Cellular Signalling, 21(9), 1444-1454 (2009)
Jing Geng et al.
Nature communications, 12(1), 3519-3519 (2021-06-12)
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR4 signal-mediated innate
Matthew C Thibodeau et al.
The Journal of biological chemistry, 299(1), 102764-102764 (2022-12-05)
The formation of complexes between Rab11 and its effectors regulates multiple aspects of membrane trafficking, including recycling and ciliogenesis. WD repeat-containing protein 44 (WDR44) is a structurally uncharacterized Rab11 effector that regulates ciliogenesis by competing with prociliogenesis factors for Rab11
Abhishek Chhetri et al.
Bio-protocol, 11(8), e3995-e3995 (2021-06-15)
(1,3)-β-d-Glucan synthase (GS) is an essential enzyme for fungal cell wall biosynthesis that catalyzes the synthesis of (1,3)-β-d-glucan, a major and vital component of the cell wall. GS is a proven target of antifungal antibiotics including FDA-approved echinocandin derivatives; however
View All Related Papers

Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service