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ER-27319

Name: ER-27319
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₂N₂O₅

CAS Number:

201010-95-9

Molecular Weight:

370.40

NACRES:

NA.77

PubChem Substance ID:

24724472

UNSPSC Code:

12352200

MDL number:

MFCD07784502

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Properties

assay

≥98% (HPLC)

form

solid

solubility

DMSO: 28 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)C(O)=O.Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C

InChI

1S/C18H20N2O.C2H2O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;3-1(4)2(5)6/h3-4,6-9H,5,10-11,19H2,1-2H3;(H,3,4)(H,5,6)

InChI key

IIELZHYJYZBSGG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ER-27319 inhibits Syk activation with an IC₅₀ = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.[1]

Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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1 of 1

This Item	S5192	H4663	A9789
Sigma-Aldrich E0656 ER-27319	Sigma-Aldrich S5192 SB 222200	Sigma-Aldrich H4663 HMBA	Sigma-Aldrich A9789 Anisomycin from Streptomyces griseolus
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form solid	form solid
solubility DMSO: 28 mg/mL	solubility DMSO: soluble ~28 mg/mL, H₂O: insoluble	solubility DMSO: soluble 34 mg/mL	solubility H₂O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.), DMSO: 20 mg/mL, methanol: 20 mg/mL
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312

pcodes

P264 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364 - P501

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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