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About This Item
Empirical Formula (Hill Notation):
C52H84N18O11
CAS Number:
Molecular Weight:
1137.34
MDL number:
UNSPSC Code:
12352200
Pricing and availability is not currently available.
Assay
≥97% (HPLC)
UniProt accession no.
storage temp.
−20°C
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Gene Information
pig ... PDYN(445529)
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Amino Acid Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg
Biochem/physiol Actions
Potent κ-agonist
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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P Slater et al.
Neuropeptides, 8(1), 71-76 (1986-07-01)
The autoradiographic distribution of kappa opioid binding sites was evaluated in sections of monkey brain using the selective ligand [3H]dynorphin1-9. Kappa receptors were highly concentrated in the deep layers of the cerebral cortex, the substantia nigra, the hippocampus and the
M G Gillan et al.
Journal of neurochemistry, 45(4), 1034-1042 (1985-10-01)
Following incubation of [3H]dynorphin A (1-8) and [3H]dynorphin A (1-9) with suspensions of guinea pig brain membranes, analysis of the supernatants by HPLC has shown that both peptides are degraded at 25 degrees C and at 0 degrees C. Bestatin
L Miller et al.
European journal of pharmacology, 116(1-2), 159-163 (1985-10-08)
The inhibitory action of dynorphin-(1-9) on the electrically stimulated mouse vas deferens was seen to be antagonised by the delta-selective opioid antagonist ICI 174864. The observed delta-receptor mediated responses were partially, but not totally, prevented by peptidase inhibitors which protect
M Maruyama et al.
Brain research, 401(1), 14-22 (1987-01-13)
This paper describes the binding properties of [3H]peptidergic opioid ligands to binding sites solubilized from rat brain membranes by the treatment with 0.125% sodium glycodeoxycholate and 1 M NaCl. The highest amount of the specific binding of [3H]-[D-Ala2-, Met5]enkephalinamide was
A I Faden et al.
Annals of neurology, 17(4), 386-390 (1985-04-01)
It has been postulated that endogenous opioids play a pathophysiological role in spinal cord injury, based on the therapeutic effects of the opiate receptor antagonist naloxone in certain experimental models. The high doses of naloxone required to exert a therapeutic
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