D1944

D4476

≥98% (HPLC), solid

• Synonym(s): 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
• Empirical Formula (Hill Notation): C₂₃H₁₈N₄O₃
• CAS Number: 301836-43-1
• Molecular Weight: 398.41
• MDL number: MFCD28391149
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798715
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: light yellow
• solubility: DMSO: ~20 mg/mL, H₂O: insoluble
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4
• InChI: 1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
• InChI key: DPDZHVCKYBCJHW-UHFFFAOYSA-N

Description

Application

D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.

Biochem/physiol Actions

D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).

D4476 may prevent or enhance apoptosis.[1] It triggers tumor suppressor p53 and impairs transcription factor E2F-1.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)