C8352
Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 0.1 mg | Please contact Customer Service for Availability | ₪2,473.00 |
About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
7
₪2,473.00
Please contact Customer Service for Availability
Related Categories
1 of 1
This Item | |||
|---|---|---|---|
| antibody form IgG fraction of antiserum | antibody form purified immunoglobulin (IgG) | antibody form IgG fraction of antiserum | antibody form affinity isolated antibody |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| Gene Information human ... CXCR4(7852) | Gene Information human ... CXCR4(7852) | Gene Information human ... CXCR4(7852) | Gene Information human ... CXCR4(7852) |
| clone polyclonal | clone polyclonal | clone polyclonal | clone polyclonal |
General description
Chemokine receptor CXCR-4 also refers as fusin or LESTR is a protein that belongs to G-protein coupled receptor 1 family. It is an essential cofactor for T cell-tropic HIV viruses into CD4+ cells. N-Terminal domain and second extracellular loop of the protein act as a HIV binding sites. Anti-CXCR4 (Fusin) (182-196) antibody can be used to block HIV-1 and HIV-2 fusion and infection of human target cells. Rabbit anti-CXCR4 (Fusin) (182-196) antibody reacts specifically with human CXCR4.
Immunogen
synthetic peptide corresponding to amino acids 182-196 of the second extracellular loop of human CXCR4.
Application
Anti-CXCR4 (Fusin) (182-196) antibody may be used in immunoblotting at a working antibody concentration of 0.5 - 1 μg/ml using human HeLa cell extract. It can also be used in immunohistochemistry.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Other Notes
The antigen (receptor) is also termed fusin, LESTER and HUMSTR.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Karin Jennbacken et al.
The Prostate, 72(8), 913-924 (2012-01-31)
Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that has completed phase II clinical trial in patients with castration resistant prostate cancer, showing promising inhibiting effects on the occurrence of metastasis and delayed disease progression. Its mechanism of action is
Raji R Nair et al.
NPJ aging and mechanisms of disease, 4, 9-9 (2018-09-06)
One of the major pathological outcomes of DNA damage during aging or anticancer therapy is enhanced inflammation. However, the underlying signaling mechanism that drives this is not well understood. Here, we show that in response to DNA damage, ubiquitously expressed
Z Lu et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6426-6431 (1997-06-10)
The chemokine receptor CXCR4 functions as a fusion coreceptor for T cell tropic and dual-tropic HIV-1 strains. To identify regions of CXCR4 that are important for coreceptor function, CXCR4-CXCR2 receptor chimeras were tested for the ability to support HIV-1 envelope
M Loetscher et al.
The Journal of biological chemistry, 269(1), 232-237 (1994-01-07)
Several chemotactic agonists including interleukin-8 (IL-8) and related cytokines have been shown to activate and attract leukocytes via seven-transmembrane domain, GTP-binding protein-coupled receptors. A cDNA clone, LESTR, encoding a protein of 352 amino acids, corresponding to a novel receptor of
Verena Schwartz et al.
FEBS letters, 583(17), 2749-2757 (2009-08-12)
MIF is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to CXCR2 and CXCR4. MIF also interacts with CD74/invariant chain, a single-pass membrane-receptor. We identified complexes between CD74 and CXCR2 with a role in leukocyte recruitment. It is
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Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C8352-.1MG | 04061832714073 |
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