C1240

Chlormethiazole hydrochloride

≥98% (HPLC), GABAA agonist, powder

• Synonym(s): 4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride
• Empirical Formula (Hill Notation): C₆H₈ClNS · HCl
• CAS Number: 6001-74-7
• Molecular Weight: 198.11
• UNSPSC Code: 12352200
• PubChem Substance ID: 329774745
• NACRES: NA.77
• MDL number: MFCD00673948
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Chlormethiazole hydrochloride, ≥98% (HPLC), powder
• description: Store desiccated
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: off-white
• solubility: H₂O: soluble >10 mg/mL
• originator: AstraZeneca
• SMILES string: Cl.Cc1ncsc1CCCl
• InChI: 1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H
• InChI key: OFXYKSLKNMTBHK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

GABA_A agonist; glycine receptor modulator.

Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H317,H318
• pcodes: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves