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C124

β-CFT naphthalenedisulfonate monohydrate

solid

Synonym(s):

(−)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate, WIN 35,428 naphthalenedisulfonate monohydrate

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About This Item

Empirical Formula (Hill Notation):
C16H20FNO2 · C10H8O6S2 · H2O
CAS Number:
77210-32-3
Molecular Weight:
583.65
NACRES:
NA.77
PubChem Substance ID:
24892389
UNSPSC Code:
12352200
MDL number:
MFCD11044874
Form:
solid
Quality level:
100

Key Documents

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form

solid

Quality Level

100

optical activity

[α]25/D −62.5°, c = 1.0 in H2O(lit.)

drug control

USDEA Schedule II

color

white

solubility

H2O: soluble

storage temp.

2-8°C

SMILES string

O.OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O.COC(=O)[C@@H]3C4CCC(C[C@@H]3c5ccc(F)cc5)N4C

InChI

1S/C16H20FNO2.C10H8O6S2.H2O/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16;/h3-6,12-15H,7-9H2,1-2H3;1-6H,(H,11,12,13)(H,14,15,16);1H2/t12-,13+,14+,15-;;/m0../s1

InChI key

XSJPWVYASBDEJI-YEVYTSHMSA-N

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This Item
SML2008239785SML0223
β-CFT naphthalenedisulfonate monohydrate solid

Sigma-Aldrich

C124

β-CFT naphthalenedisulfonate monohydrate

Tiotropium bromide monohydrate ≥98% (HPLC)

Sigma-Aldrich

SML2008

Tiotropium bromide monohydrate

Cyclophosphamide Monohydrate A widely used anti-neoplastic agent that also displays immunosuppressant properties.

Sigma-Aldrich

239785

Cyclophosphamide Monohydrate

Zoledronic acid monohydrate ≥98% (HPLC)

Sigma-Aldrich

SML0223

Zoledronic acid monohydrate

form

solid

form

powder

form

solid

form

powder

drug control

USDEA Schedule II

drug control

-

drug control

-

drug control

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: soluble

solubility

H2O: 2 mg/mL, clear

solubility

water: 30 mg/mL

solubility

H2O: ≥2 mg/mL

color

white

color

white to beige

color

white

color

white to beige

Biochem/physiol Actions

Cocaine analog that inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of 26.1 nM, 31.9 nM, and 127 nM, respectively. [11C]-β-CFT and [18F]-β-CFT are ligands for PET imaging of the dopamine transporter in vivo.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
125K46033
125K46032
125K46031
125K4603
085K4626

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Yan-Fen Zhang et al.
Nuclear medicine and biology, 38(8), 1205-1212 (2011-07-12)
Alterations of dopamine in striatal presynaptic terminals play an important role in the hypoxic-ischemic (HI) brain injury. Quantification of DAT levels in the presynaptic site using (11)C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane ((11)C-CFT) with positron emission tomography (PET) was applied in studies for Parkinson's disease.
Y Ouchi et al.
Annals of neurology, 45(5), 601-610 (1999-05-13)
We investigated changes in the kinetics in the binding of the dopamine transporter probe 2-beta-carbomethoxy-3beta-(4-[11C]fluorophenyl)tropane (beta-CFT) in living brain by compartmental analysis, using positron emission tomography in unmedicated patients with Parkinson's disease (PD) (Hoehn and Yahr stages I-II). With dynamic
Imaging striatal dopaminergic function in phospholipase A2 group VI-related parkinsonism.
Pankaj Agarwal et al.
Movement disorders : official journal of the Movement Disorder Society, 27(13), 1698-1699 (2012-11-30)
U Scheffel et al.
Synapse (New York, N.Y.), 23(2), 61-69 (1996-06-01)
[11C]WIN 35,428 (also designated [11C]CFT) is now being used in several positron emission tomography (PET) centers to image dopamine (DA) transporter sites in the mammalian brain. Whether and to what extent in vivo WIN 35,428 binding is influenced by intra-
F J Lee et al.
The Journal of biological chemistry, 271(34), 20885-20894 (1996-08-23)
In order to delineate structural motifs regulating substrate affinity and recognition for the human dopamine transporter (DAT), we assessed [3H]dopamine uptake kinetics and [3H]CFT binding characteristics of COS-7 cells transiently expressing mutant DATs in which the COOH terminus was truncated
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Global Trade Item Number

SKUGTIN
C124-5MG04061832089560

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