B4063
BIMU8 hydrate
≥98% (HPLC)
Synonym(s):
2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide Hydrochloride (1:1) hydrate
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About This Item
Empirical Formula (Hill Notation):
C19H26N4O2·HCl · xH2O
CAS Number:
Molecular Weight:
378.90 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
off-white to light tan
solubility
H2O: ≥5 mg/mL
storage temp.
2-8°C
SMILES string
Cl.N1([C@@H]2C[C@H](C[C@H]1CC2)NC(=O)N3c4c(cccc4)N(C3=O)C(C)C)C.O
InChI
1S/C19H26N4O2.ClH.H2O/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3;;/h4-7,12-15H,8-11H2,1-3H3,(H,20,24);1H;1H2/t13-,14+,15-;;
InChI key
HZJJVFOOACXPTH-XZAJHMFNSA-N
Biochem/physiol Actions
BIMU8 hydrate is a potent 5-HT4 serotonin receptor agonist.
BIMU8 hydrate is a potent 5-HT4 serotonin receptor agonist. Serotonin (5-HT) is a major neurotransmitter that acts through a family of GPCRs and one ion channel. 5-HT4 receptor is GPCR expressed in many tissues, including brain, and modulates dopamine secretion, learning, and memory. BIMU8 is a full agonist at 5-HT4, but it binds differently than the endogenous ligand, 5-HT, shown through site-directed mutagenesis studies. It depolarizes neurons and was used to localize 5-HT4 to somatic but not dendritic regions of CA1 pyramidal neurons.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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N Galeotti et al.
The Journal of pharmacology and experimental therapeutics, 286(3), 1115-1121 (1998-09-11)
The effects of the administration of different 5-HT4 receptor antagonists (SDZ 205557, GR 125487) and 5-HT4 receptor agonists (BIMU 1, BIMU 8) on memory processes were evaluated in the mouse passive avoidance test. The administration of SDZ 205557 (10 mg
S Letty et al.
Neuropharmacology, 36(4-5), 681-687 (1997-04-01)
Serotonin (5-HT) is involved in a large variety of physiological functions and it appears now that it could play a role in cognitive processes through the activation of 5-HT4 receptors. The present study was conducted to determine the effect of
E Monferini et al.
Life sciences, 52(9), PL61-PL65 (1993-01-01)
Recently, a 5-hydroxytryptamine (5-HT) receptor has been described, whose pharmacology was distinct from that of the already known serotonergic receptors, so that it has been called 5-HT4. Because the lack of a high affinity radioligand, the identification of this receptor
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B4063-5MG | 04061832079325 |
| B4063-25MG | 04061832079318 |