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B107

L-BMAA hydrochloride

≥97% (NMR), neurotoxin, powder

Synonym(s):

S(+)-2-Amino-3-(methylamino)propionic acid hydrochloride

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10 mg
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₪660.00
50 mg
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₪2,572.00

About This Item

Empirical Formula (Hill Notation):
C4H10N2O2 · HCl
CAS Number:
16012-55-8
Molecular Weight:
154.60
UNSPSC Code:
12352209
PubChem Substance ID:
329773160
NACRES:
NA.32
MDL number:
MFCD00055227
Assay:
≥97% (NMR)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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Product Name

L-BMAA hydrochloride, ≥97% (NMR), powder

Quality Level

100

assay

≥97% (NMR)

form

powder

optical activity

[α]/D +21 to +31°, c = 0.5 M in 0.1 M HCl(lit.)

storage condition

desiccated

color

white to beige

solubility

H2O: soluble (solutions may be stored for several days at 4 °C)

storage temp.

−20°C

SMILES string

Cl.CNC[C@H](N)C(O)=O

InChI

1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1

InChI key

VDXYGASOGLSIDM-DFWYDOINSA-N

General description

L-BMAA hydrochloride/β-N-methylamino-l-alanine (BMAA) is a cyanobacterial neurotoxin.

Application

L-BMAA hydrochloride has been used as a standard to compare all the samples in the analysis of β-N-methylamino-l-alanine (BMAA) isomers in desert crust material. It has also been used as an additive with f/2+Si medium to treat the cells of Phaeodactylum tricornutum and Thalassiosira weissflogii to study its effect on them.

Biochem/physiol Actions

L-BMAA hydrochloride helps to block the addition of heparan sulfate to glypican-1. It possesses unusual glutamate receptor binding properties. It may cause amyotrophic lateral sclerosis/Lou Gehrig′s disease.[1]

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A0779A1784B016
L-BMAA hydrochloride ≥97% (NMR), powder

Sigma-Aldrich

B107

L-BMAA hydrochloride

p-Aminoclonidine hydrochloride solid

Sigma-Aldrich

A0779

p-Aminoclonidine hydrochloride

Aminopterin powder

Sigma-Aldrich

A1784

Aminopterin

Benoxathian hydrochloride solid

Sigma-Aldrich

B016

Benoxathian hydrochloride

form

powder

form

solid

form

powder

form

solid

assay

≥97% (NMR)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

H2O: soluble (solutions may be stored for several days at 4 °C)

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C), boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C), 0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C), methanol: soluble (Solutions may be stored for several days at 4 °C)

solubility

2 M NaOH: 50 mg/mL (Solutions may be stored for 1-2 days at 4°C.)

solubility

H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.), ethanol: soluble, isopropanol: soluble

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000450088
0000450088
0000440271
0000440272
0000440271

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Neurotoxic amino acids and their isomers in desert environments
Metcalf JS, et al.
Journal of arid environments, 140-144 (2015)
David A Davis et al.
Journal of neuropathology and experimental neurology, 79(4), 393-406 (2020-02-23)
The early neuropathological features of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are protein aggregates in motor neurons and microglial activation. Similar pathology characterizes Guamanian ALS/Parkinsonism dementia complex, which may be triggered by the cyanotoxin β-N-methylamino-l-alanine (BMAA). We report here the
Olga A Koksharova et al.
Toxins, 12(6) (2020-06-10)
All cyanobacteria produce a neurotoxic non-protein amino acid β-N-methylamino-L-alanine (BMAA). However, the biological function of BMAA in the regulation of cyanobacteria metabolism still remains undetermined. It is known that BMAA suppresses the formation of heterocysts in diazotrophic cyanobacteria under nitrogen
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Global Trade Item Number

SKUGTIN
B107-50MG04061833420553
B107-10MG04061833420515

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