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A5686

Sigma-Aldrich

Arg-Gly-Glu-Ser acetate salt

≥95% (HPLC)

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2 MG
₪522.00
5 MG
₪1,072.00
10 MG
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₪522.00

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2 MG
₪522.00
5 MG
₪1,072.00
10 MG
₪2,007.00

About This Item

Empirical Formula (Hill Notation):
C16H29N7O8
CAS Number:
159002-32-1
Molecular Weight:
447.44
MDL number:
MFCD00133106
UNSPSC Code:
12352202
PubChem Substance ID:
329770831
NACRES:
NA.32

₪522.00

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biological source

synthetic (organic)

Assay

≥95% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(O)=O.N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O

InChI

1S/C16H29N7O8.C2H4O2/c17-8(2-1-5-20-16(18)19)13(28)21-6-11(25)22-9(3-4-12(26)27)14(29)23-10(7-24)15(30)31;1-2(3)4/h8-10,24H,1-7,17H2,(H,21,28)(H,22,25)(H,23,29)(H,26,27)(H,30,31)(H4,18,19,20);1H3,(H,3,4)/t8-,9-,10-;/m0./s1

InChI key

SALKOFBHHIHLSW-PUBMXKGKSA-N

Gene Information

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

Amino Acid Sequence

Arg-Gly-Glu-Ser

Application

Arg-Gly-Glu-Ser acetate salt has been used:
  • as an integrin blocking peptide to study its effects on ciliary neurotrophic factor (CNTF) regulation in astroglioma cells[1]
  • as a control peptide to study its effects on the binding of patient IgG to integrin αvβ6[2]
  • as an integrin inhibitor peptide to study its effects on cell adhesion in Capsaspora owczarzaki cells[3]

Biochem/physiol Actions

Arg-Gly-Glu-Ser peptide acts as an integrin-blocking peptide.[1]
Inhibitor of platelet aggregation

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCJ5343
SLCH5094
SLCC1664
SLBW8777
SLBW5172

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Helena Parra-Acero et al.
Current biology : CB, 30(21), 4270-4275 (2020-08-29)
In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors mediating cell-matrix adhesion in animals. They are heterodimeric transmembrane proteins that
Seong Su Kang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(27), 9277-9287 (2012-07-06)
Ciliary neurotrophic factor (CNTF) is a potent neural cytokine with very low expression in the CNS, predominantly by astrocytes. CNTF increases rapidly and greatly following traumatic or ischemic injury. Understanding the underlying mechanisms would help to design pharmacological treatments to
Changsuk Moon et al.
Respiratory research, 10, 18-18 (2009-03-11)
Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory responses to intratracheal (i.t.) lipopolysaccharide (LPS) treatment and on the integrin signaled mitogen-activated protein
Gartner, T.K., et al.
Blood, 66, 305a-305a (1985)
Takeshi Kuwada et al.
Gastroenterology, 160(7), 2383-2394 (2021-02-15)
Ulcerative colitis is the most frequent type of inflammatory bowel disease and is characterized by colonic epithelial cell damage. Although involvement of autoimmunity has been suggested in ulcerative colitis, specific autoantigens/antibodies have yet to be elucidated. Using 23 recombinant integrin
View All Related Papers

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