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A3773

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

≥99%

Synonym(s):

THA hydrochloride hydrate, Tacrine hydrochloride, Tetrahydroaminacrine hydrochloride hydrate

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1 g
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₪274.00
5 g
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₪782.00

About This Item

Empirical Formula (Hill Notation):
C13H14N2 · HCl · xH2O
CAS Number:
206658-92-6
Molecular Weight:
234.72 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24278139
UNSPSC Code:
51111800
MDL number:
MFCD00150067
Assay:
≥99%
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥99%

form

powder

mp

284-286 °C (lit.)

solubility

H2O: soluble

SMILES string

O.Cl.Nc1c2CCCCc2nc3ccccc13

InChI

1S/C13H14N2.ClH.H2O/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H;1H2

InChI key

PXGRMZYJAOQPNZ-UHFFFAOYSA-N

Gene Information

human ... ACHE(43)

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
A7410A79922PZ0136
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate ≥99%

Sigma-Aldrich

A3773

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

Amiloride hydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

A7410

Amiloride hydrochloride hydrate

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate ≥99%

Sigma-Aldrich

A79922

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

CP-100263 dihydrochloride hydrate ≥97% (HPLC)

Sigma-Aldrich

PZ0136

CP-100263 dihydrochloride hydrate

assay

≥99%

assay

≥98% (HPLC)

assay

≥99%

assay

≥97% (HPLC)

form

powder

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

solubility

H2O: soluble

solubility

H2O: 50 mg/mL, hazy (Very Faint Yellow to Dark Yellow and Very Faint Green-Yellow to Dark Green-Yellow and Very Faint Brown-Yellow to Dark Brown-Yellow)

solubility

-

solubility

H2O: ≥5 mg/mL

mp

284-286 °C (lit.)

mp

285-288 °C (dec.)

mp

284-286 °C (lit.)

mp

-

Gene Information

human ... ACHE(43)

Gene Information

human ... ABP1(26), ACCN1(40), ACCN2(41), PLAU(5328), SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), TNF(7124)
mouse ... Abp1(76507), Accn1(11418), Accn2(11419), Plau(18792), Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278), Slc9a1(20544)
rat ... Abp1(65029), Accn1(25364), Accn2(79123), Plau(25619), Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782)

Gene Information

-

Gene Information

-

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000257141
0000234461
0000223246
0000223246
0000234461

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M Harel et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(19), 9031-9035 (1993-10-01)
Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes with ligands were determined at 2.8-A resolution. In a complex with edrophonium, and quaternary nitrogen of the ligand
Go Koganemaru et al.
Pharmacology, biochemistry, and behavior, 126, 103-108 (2014-09-30)
We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats. Rats received intraperitoneal injection of cabergoline (0.5, 1.0, or 5.0mg/kg), rotigotine (1.0, 2.5, or 10.0mg/kg), or vehicle 30min before intraperitoneal injection
Dietrich E Lorke et al.
Molecules (Basel, Switzerland), 25(7) (2020-04-02)
Organophosphates (OPCs), useful agents as pesticides, also represent a serious health hazard. Standard therapy with atropine and established oxime-type enzyme reactivators is unsatisfactory. Experimental data indicate that superior therapeutic results can be obtained when reversible cholinesterase inhibitors are administered before
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Global Trade Item Number

SKUGTIN
A3773-5G04061832945255
A3773-10G04061832945248
A3773-1G04061833367889

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