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A1276

Amastatin hydrochloride hydrate

powder, ≥97% (HPLC)

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Synonym(s):

(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrochloride hydrate

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0.5 mg
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₪828.00
1 mg
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₪1,419.00
5 mg
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₪4,874.00
10 mg
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25 mg
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About This Item

Empirical Formula (Hill Notation):
C21H38N4O8 · HCl · xH2O
CAS Number:
Molecular Weight:
511.01 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
8888370

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Product Name

Amastatin hydrochloride hydrate, ≥97% (HPLC)

biological source

synthetic (organic)

Quality Segment

assay

≥97% (HPLC)

form

powder

input

general use sample(s)

mp

202-205 °C

solubility

methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)

antibiotic activity spectrum

neoplastics

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

Cl[H].[H]O[H].CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C21H38N4O8.ClH.H2O/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H;1H2/t12-,13+,15+,16+,17+;;/m1../s1

InChI key

WBYDQJQQTMJMQH-AFROIDPFSA-N

General description

Chemical structure: peptide

Biochem/physiol Actions

Amastatin is a slow, tight-binding inhibitor of aminopeptidases. It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts Angiotensin II to Angiotensin III. Effective concentration: 1-10 μM.
It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.

Effective concentration: 1-10 μM.

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This Item
A6191B8385S9007
description

≥97% (HPLC)

description

protease inhibitor

description

≥98% (HPLC)

description

potency: ≥603 μg per mg

biological source

synthetic (organic)

biological source

Streptomyces sp.

biological source

synthetic (organic)

biological source

synthetic (inorganic)

assay

≥97% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

200

form

powder

form

lyophilized powder

form

powder

form

powder

solubility

methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)

solubility

DMSO: soluble, ethanol: soluble, H2O: 50 mg/mL, 1-propanol: soluble, methanol: soluble, 1-butanol: soluble

solubility

water: 25 mg/mL, clear to very slightly hazy, colorless

solubility

H2O: soluble 50 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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