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02582

Sigma-Aldrich

4-Pyridoxolactone

≥98.5% (HPLC)

Synonym(s):

β-Pyracin, 4-Pyridoxic acid lactone, 7-Hydroxy-6-methylfuro[3,4-c]pyridin-1(3H)-one

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About This Item

Empirical Formula (Hill Notation):
C8H7NO3
CAS Number:
4753-19-9
Molecular Weight:
165.15
Beilstein:
140752
MDL number:
MFCD13179358
UNSPSC Code:
12352205
PubChem Substance ID:
329747468
NACRES:
NA.79

Assay

≥98.5% (HPLC)
98.5-101.5% (T)

form

powder

technique(s)

HPLC: suitable

color

white to light yellow

storage temp.

−20°C

SMILES string

O=C1OCC2=CN=C(C)C(O)=C21

InChI

1S/C8H7NO3/c1-4-7(10)6-5(2-9-4)3-12-8(6)11/h2,10H,3H2,1H3

InChI key

HHPDVQLBYQFYFA-UHFFFAOYSA-N

Biochem/physiol Actions

4-Pyridoxolactone is a bacterial oxidation metabolite of vitamin B6.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nana Yokochi et al.
The Journal of biological chemistry, 279(36), 37377-37384 (2004-07-01)
Microbacterium luteolum YK-1 has pyridoxine degradation pathway I. We have cloned the structural gene for the second step enzyme, pyridoxal 4-dehydrogenase. The gene consists of 1,026-bp nucleotides and encodes 342 amino acids. The enzyme was overexpressed under cold shock conditions
Junichi Funami et al.
Biochimica et biophysica acta, 1753(2), 234-239 (2005-10-18)
4-Pyridoxolactonase is involved in the degradation pathway for pyridoxine, a free form of vitamin B6. The gene (mlr6805) encoding the putative 4-pyridoxolactonase of nitrogen fixing symbiotic microorganism Mesorhizobium loti MAFF303099 has been identified based on the genome database. The gene
Saki Nishimura et al.
Journal of nutritional science and vitaminology, 54(1), 18-24 (2008-04-05)
A determination method for individual natural vitamin B(6) compounds was developed. The vitamin B(6) compounds were specifically converted into 4-pyridoxolactone (PAL), a highly fluorescent compound, through a combination of enzymatic reactions and HCl-hydrolysis. PAL was then determined by HPLC. Pyridoxal
Z Bannur et al.
Clinical biochemistry, 47(6), 427-431 (2014-03-04)
Acute lymphoblastic leukaemia (ALL) has posed challenges to the clinician due to variable patients' responses and late diagnosis. With the advance in metabolomics, early detection and personalised treatment are possible. Metabolomic profile of 21 ALL patients treated with 6-mercaptopurine and
P Edwards et al.
Clinica chimica acta; international journal of clinical chemistry, 190(1-2), 67-80 (1990-09-01)
The effects of increased intake of pyridoxine hydrochloride on plasma vitamin B6 metabolism within therapeutic limits (up to 800 mg/day) were investigated. Maximum plasma concentrations of pyridoxal phosphate were attained at relatively low intakes of pyridoxine hydrochloride. Two metabolism thought
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