T6508

Trifluoroacetic acid

ReagentPlus^®, 99%

• Synonym(s): TFA
• Linear Formula: CF₃COOH
• CAS Number: 76-05-1
• Molecular Weight: 114.02
• Beilstein: 742035
• EC Number: 200-929-3
• MDL number: MFCD00004169
• UNSPSC Code: 12352106
• PubChem Substance ID: 329826846
• NACRES: NA.21

Properties

• vapor density: 3.9 (vs air)
• Quality Level: 200
• vapor pressure: 97.5 mmHg ( 20 °C)
• product line: ReagentPlus^®
• Assay: 99%
• form: liquid
• impurities: ≤0.05% water
• refractive index: n20/D 1.3 (lit.)
• pH: 1 (10 g/L)
• bp: 72.4 °C (lit.)
• mp: −15.4 °C (lit.)
• solubility: ethanol: soluble 0.33 mL/mL
• density: 1.489 g/mL at 20 °C (lit.)
• SMILES string: OC(C(F)(F)F)=O
• InChI: 1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: DTQVDTLACAAQTR-UHFFFAOYSA-N

Description

General description

Trifluoroacetic acid (TFA) is an organofluorine compound used as a reagent in organic synthesis for various acid-catalyzed reactions such as ring-opening of epoxides, biomimetic cyclization, Cope rearrangements, and natural product synthesis. TFA′s physicochemical characteristics provide advantages over other acids because of its high volatility, solubility in organic solvents, and acidic strength. When TFA is used as a reagent the product isolation is simple by evaporation due to its very high volatility. Less volatile acids such as sulfuric acid or p-toluenesulfonic acid may require neutralization or an extractive workup.[1]

Application

Trifluoroacetic acid can be used as a reagent:      

• For the cleavage of nitrogen and oxygen protecting groups such as N-Boc, N-benzyloxymethyl, benzyl ether, p-methoxybenzyl ether, t-butyl ether, t-butyloxymethyl ether, triphenylmethyl ether, and dimethyl acetals.[1][2][3]      
• In the Baeyer–Villiger oxidation reactions in combination with sodium percarbonate.[1],·      
• For the C-H trifluoromethylation of arenes.[4]

TFA can also be used as:      

• A solvent in atom transfer cyclization reactions and polymer processes.[2]      
• A catalyst in the synthesis of ε-caprolactam via Beckmann rearrangement of cyclohexanone oxime in aprotic solvents.[5]

Packaging

1mL in each ampule.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H314,H332,H412
• Precautionary Statements: P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 2