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Y0000108

Trihexyphenidyl hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H31NO · HCl
CAS Number:
52-49-3
Molecular Weight:
337.93
MDL number:
MFCD00058212
UNSPSC Code:
41116107
PubChem Substance ID:
329830848
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

trihexyphenidyl hydrochloride

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3

InChI

1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H

InChI key

QDWJJTJNXAKQKD-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Trihexyphenidyl hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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[Case report: a case of anterocollis ameliorated by trihexyphenidyl].
Ayako Shioya et al.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 100(11), 3325-3328 (2012-01-19)
Bradley James Robottom et al.
The neurologist, 17(6), 340-341 (2011-11-03)
Trihexyphenidyl is 1 of the most effective agents for treatment of young-onset dystonia. As such, women of childbearing potential use trihexyphenidyl despite inadequate information about potential effects on pregnancy, labor, and fetal development. We report 2 uncomplicated pregnancies in 1
Alex Pollock et al.
The Cochrane database of systematic reviews, (10)(10), CD008389-CD008389 (2011-10-07)
Eye movement disorders may affect over 70% of stroke patients. These eye movement disorders can result in difficulty maintaining the normal ocular position and difficulty moving the eyes appropriately. The resulting functional disabilities include a loss of depth perception, reduced
Clinical reasoning: A 13-year-old boy presenting with dystonia, myoclonus, and anxiety.
Joanna S Blackburn et al.
Neurology, 78(11), e72-e76 (2012-03-14)
Yasumasa Yoshiyama et al.
Neurobiology of disease, 45(1), 329-336 (2011-09-06)
Anticholinergics, and drugs with anticholinergic properties, are widely and frequently prescribed, especially to the elderly. It is well known that these drugs decrease cognitive function and increase the risk of dementia. Although the mechanism of anticholinergic drug-induced cognitive impairment has
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