The utilization of ion-pairing reagents as mobile phase additives allows the elution of ionic and highly polar substances using reversed phase HPLC columns. The purity of mobile phase additives is a prime factor to their successful application. Sigma-Aldrich offers an outstanding collection of tailor-made reagents for anionic (quaternary ammonium and phosphonium salts) and cationic (alkanesulfonates) analyzes. All mobile phase additives are rigorously tested with special emphasis on the requirements of modern reversed phase HPLC:
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Journal of controlled release : official journal of the Controlled Release Society, 116(1), 50-57 (2006-10-20)
Parallel Artificial Membrane Permeability Assay (PAMPA) is a method to screen drug candidates for membrane permeability. The objective was to characterize the transport of a model weak base, metoprolol, across a three lipid-component PAMPA system (denoted A-PAMPA, for anionic-PAMPA) and
Journal of chromatography, 581(1), 57-63 (1992-10-02)
A simple and efficient procedure has been developed for the derivatization of diuretic agents in human urine by direct extractive alkylation and their detection by gas chromatography-mass spectrometry. The procedure is an improvement over previous extractive alkylation methods because of
Journal of chromatography. B, Biomedical sciences and applications, 691(2), 305-312 (1997-04-11)
The objective of this research was to develop a rapid, sensitive and reliable method for the separation of phosphonodipeptide prodrugs and parent compounds to facilitate the evaluation of cell permeation using in vitro cell culture models. Separation was accomplished isocratically
Journal of biomedical materials research. Part A, 80(4), 852-860 (2006-10-31)
Although much effort has been extended to the efficient cancer therapies, the drug resistance is still a major obstacle in cancer chemotherapeutic treatments. Almost 90% of the cancer therapy failure is caused by the relative problems. Recently, the application of
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