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27285

Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

Synonym(s):

Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2

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500 G
₪1,181.00
1 KG
₪1,615.00
6 X 1 KG
₪8,395.00

₪1,181.00

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500 G
₪1,181.00
1 KG
₪1,615.00
6 X 1 KG
₪8,395.00

About This Item

Empirical Formula (Hill Notation):
C10H14N2Na2O8 · 2H2O
CAS Number:
6381-92-6
Molecular Weight:
372.24
Beilstein:
3900609
EC Number:
205-358-3
UNSPSC Code:
12352107
PubChem Substance ID:
24856480
NACRES:
NA.77

₪1,181.00

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Agency

tested according to BP
tested according to Ph. Eur.
tested according to USP

Quality Level

200

reg. compliance

tested according to FCC

Assay

99.0-101.0%

form

crystals

quality

meets analytical specification of Ph. Eur., BP, USP, FCC

reaction suitability

reagent type: chelator

impurities

residual solvents, complies
≤0.001% cyanide (CN)
≤0.001% heavy metals (as Pb)
≤0.1% nitrilotriacetic acid (HPLC) (HPLC)

loss

8.7-11.4% loss on drying, 200 °C, 3 h

pH

4-5 (20 °C, 5%)

mp

248 °C (dec.) (lit.)

solubility

water: soluble 100 g/L at 20 °C

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg

cation traces

As: ≤1 mg/kg
Ca:, in accordance
Fe: ≤10 mg/kg
Pb: ≤10 mg/kg

application(s)

pharmaceutical (small molecule)

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

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General description

Ethylenediaminetetraacetic acid disodium salt dihydrate, referred to as EDTA is a widely used chelator of divalent cations like Ca⁺². It can inhibit proteases dependent on metal ions, such as, calcium-dependent cysteine proteases. EDTA also acts as a chelator of the Zn ion, inhibiting metalloproteases that require zinc for activity.

Application

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na2HPO4 and citric acid for preparing Na2EDTA-McIlvaine buffer.[1] Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production[2]

Other Notes

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comparable product

Product No.
Description
Pricing

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H332,H373

Hazard Classifications

Acute Tox. 4 Inhalation - STOT RE 2 Inhalation

Target Organs

Respiratory Tract

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB0873
STBL1584
STBL0230
STBL2916
STBL0160

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Evaluation of EDTA as the chelator in the biuret reagent.
H Van Kley et al.
Clinical chemistry, 19(6), 621-623 (1973-06-01)
Haruthai Sangjarusvichai et al.
Talanta, 79(4), 1036-1041 (2009-07-21)
In this report, we aimed to extend our previous efforts toward the evaluation of sulfonamides (SAs) with a boron-doped diamond (BDD) electrode. We improved this method by reducing the analysis time using a monolithic column coupled with amperometric detection to
Solvent-free hydrothermal synthesis of anatase TiO2nanoparticleswith enhanced photocatalytic hydrogen production activity.
Ayad F. Alkaim
Applied Catalysis A: General, 466, 32- 37 (2013)
Sinan Akbayram et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(5), 494-496 (2010-06-10)
Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to antiplatelet antibodies that cause platelet clumping in blood anticoagulated with EDTA. The aggregation of platelets in EDTA-dependent PTCP is usually prevented by other anticoagulants
Sabrina Lusvarghi et al.
Nucleic acids research, 41(13), 6637-6649 (2013-05-04)
Interaction between the viral protein Rev and the RNA motifs known as Rev response elements (RREs) is required for transport of unspliced and partially spliced human immunodeficiency virus (HIV)-1 and HIV-2 RNAs from the nucleus to the cytoplasm during the
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What is the grade of Product No. 27285?

    1 answer

    1. Product 27285 is a reagent that meets the analytical specification of Ph. Eur., BP, USP, FCC. Ph.

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