06725
N-(2-Aminoethyl)-5-isoquinolinesulfonamide hydrochloride
≥97.0% (HPLC)
Synonym(s):
H-9
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C11H13N3O2S · HCl
CAS Number:
Molecular Weight:
287.77
Beilstein:
6548866
MDL number:
UNSPSC Code:
12352202
Assay
≥97.0% (HPLC)
solubility
methanol: 1 mg/mL, clear, colorless
SMILES string
Cl.NCCNS(=O)(=O)c1cccc2cnccc12
Biochem/physiol Actions
Selective casein kinase 1 inhibitor. Potent inhibitor of histamine release from human basophils when induced by phorbol ester or DiC8, but not when induced by anti-IgE, fMLP (formyl-Met-Leu-Phe) and calcium ionophore A23187. This implicates divergent pathways of basophil activation.
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.
If you need assistance, please contact Customer Support.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
D O Thueson et al.
Biochemical and biophysical research communications, 144(2), 732-740 (1987-04-29)
The release of histamine and other inflammatory mediators from human basophils is triggered by numerous stimuli, including chemical, physical and receptor-mediated activators. Several mechanisms of cell activation including protein kinase C activation have been proposed to operate in these cells.
T Chijiwa et al.
The Journal of biological chemistry, 264(9), 4924-4927 (1989-03-25)
When screening various isoquinolinesulfonamide compounds which we synthesized, CKI-7, N-(2-amino-ethyl)-5-chloroisoquinoline-8-sulfonamide, was found to have a potent inhibitory action against casein kinase I and a much weaker effect on casein kinase II and other protein kinases. Kinetic analysis indicated that CKI-7
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service