Our R&D team conducted spike recovery and dilution linearity tests in rat serum samples. The sequence for both rat and mouse is identical. Although we attempted to develop this kit for both rat and mouse, the recovery in rats was considerably lower compared to mice. As a result, we do not recommend this kit for use with rats. Verification tests were not carried out in cerebrospinal fluid (CSF) or rat brain samples to assess potential improvement in recovery for other sample types.
HNDG4MAG-36K
MILLIPLEX® Human Neurodegenerative Disease Magnetic Bead Panel 4 - Neuroscience Multiplex Assay
The analytes available for this multiplex kit are: Amyloid β40, Amyloid β42, GDNF, sRAGE, S100B.
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
To order a Milliplex® kit, please search for your analyte of interest.
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Quality Level
species reactivity
human
manufacturer/tradename
Milliplex®
assay range
accuracy: 84-108%
standard curve range: 14-10,000 pg/mL
(S100B)
standard curve range: 21-15,000 pg/mL
(sRAGE)
standard curve range: 27-20,000 pg/mL
(Amyloid β42)
standard curve range: 3-2,500 pg/mL
(Amyloid β40)
standard curve range: 7-5,000 pg/mL
(GDNF)
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex xMAP)
shipped in
wet ice
General description
The MILLIPLEX® Human Neurodegenerative Bead Panel 4 is to be used for the simultaneous quantification of the following 5 analytes in any combination in human cerebrospinal fluid (CSF): S100B, Amyloid β40 (Aβ1-40), Amyloid β42 (Aβ1-42), sRAGE, and GDNF. This kit is not validated for testing serum or cell culture supernatants.
Panel Type: Neuroscience
Panel Type: Neuroscience
Specificity
Cross Reactivty
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Application
- Analytes: Amyloid β40, Amyloid β42, GDNF, sRAGE, S100B
- Recommended Sample type: CSF
- Recommended Sample dilution: 1:3
- Assay Run Time: Overnight
- Research Category: Neuroscience
Features and Benefits
Design your multiplex kit by choosing available analytes within this panel.
Packaging
Everything you need in a single kit.
Storage and Stability
Recommended storage for kit components is 2 - 8°C.
Other Notes
Sensitivity: Refer to kit protocol for sensitivities of individual analytes.
Legal Information
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Nicholas J Justice et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2612-2623 (2015-02-13)
Recent studies have found that those who suffer from posttraumatic stress disorder (PTSD) are more likely to experience dementia as they age, most often Alzheimer's disease (AD). These findings suggest that the symptoms of PTSD might have an exacerbating effect
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Neuroscience multiplex assays, such as MILLIPLEX® multiplex assays, enable simultaneous measurement of neuroscience-related biomarkers to gain a better picture of neurodegenerative diseases, neurological disorders, and neuropeptide/neurohormone signaling.
Learn how multiplex detection of Alzheimer’s disease biomarkers, using the MILLIPLEX® Human Amyloid Beta and Tau Magnetic Bead Panel, allows for a different perspective on neurodegenerative disease research.
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Is the Milliplex Mouse Amyloid Beta Panel (MABMAG-83K) suitable for testing rat samples?
1 answer-
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What is the reason that GLP-1 total and active cannot be run together in HMHEMAG-34K?
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The same capture is used for both total and active GLP-1; however, the detection is specific to either total or active GLP-1.
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