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Anti-Cdk2 Antibody, clone AN4.3

Name: Anti-Cdk2 Antibody, clone AN4.3
Brand: MM
Price: 1877 ILS

clone AN4.3, Upstate^®, from mouse

Synonym(s):

Anti-CDKN2, Anti-p33(CDK2)

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Pack Size	SKU	Availability	Price
200 μg		Please contact Customer Service for Availability	₪1,877.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

AN4.3, monoclonal

Application:

IP, WB

Citations:

₪1,877.00

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Properties

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

AN4.3, monoclonal

species reactivity

mouse, Xenopus, human

manufacturer/tradename

Upstate^®

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_001798

UniProt accession no.

P24941

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

mouse ... Cdk2(12566)

Description

General description

33kDa

Immunogen

Recombinant human cdk2

Application

0.5-2μg/ml of this lot detected cdk2 in HeLa nuclear extract. 4μg of a previous lot immunoprecipitated cdk2 from 500μg of mouse 3T3 nuclear extract.

Detect Cdk2 with Anti-Cdk2 Antibody, clone AN4.3 (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Biochem/physiol Actions

cdk2, does not react with other cdks

Physical form

0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide, and 30% glycerol.

Format: Purified

Protein G Chromatography

Preparation Note

2 years at -20°C

Analysis Note

Control
Positive Antigen Control: Catalog #12-309, Hela cell nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.

routinely evaluated by immunoblot on HeLa nuclear extract

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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1 of 1

This Item	07-631	06-966	06-923
Sigma-Aldrich 05-596 Anti-Cdk2 Antibody, clone AN4.3	Sigma-Aldrich 07-631 Anti-cdk2 Antibody	Sigma-Aldrich 06-966 Anti-CDK1/CDC2 Antibody (C-Term)	Sigma-Aldrich 06-923 Anti-Cdk1/Cdc2 (PSTAIR) Antibody
species reactivity mouse, Xenopus, human	species reactivity human	species reactivity mouse	species reactivity human, rat, amphibian, mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source rabbit	biological source rabbit	biological source rabbit
antibody form purified antibody	antibody form purified antibody	antibody form serum	antibody form affinity isolated antibody
clone AN4.3, monoclonal	clone polyclonal	clone polyclonal	clone polyclonal
Gene Information mouse ... Cdk2(12566)	Gene Information human ... CDK2AP1(8099)	Gene Information hamster ... Cdk1(100766716) human ... CDK1(983) mouse ... Cdk1(12534) rat ... Cdk1(54237)	Gene Information chicken ... Cdk1(396252) dog ... Cdk1(100856079) frog ... Cdk1(394503) fruit fly ... Cdk1(34411) human ... CDK1(983) mouse ... Cdk1(12534) rat ... Cdk1(54237)

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

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Telomerase regulation during entry into the cell cycle in normal human T cells.

K J Buchkovich et al.

Molecular biology of the cell, 7(9), 1443-1454 (1996-09-01)

Telomerase activity is involved in telomere length maintenance. Leukocytes, unlike many human somatic tissues, have detectable telomerase activity. These cells provide a normal human cell type in which to study telomerase. We studied the regulation of telomerase activity and the

A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase.

Nandini Sakurikar et al.

Oncotarget, 7(2), 1380-1394 (2015-11-26)

DNA damage activates Checkpoint kinase 1 (Chk1) to halt cell cycle progression thereby preventing further DNA replication and mitosis until the damage has been repaired. Consequently, Chk1 inhibitors have emerged as promising anticancer therapeutics in combination with DNA damaging drugs

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma.

Sara Bolin et al.

Oncogene, 37(21), 2850-2862 (2018-03-08)

Medulloblastoma (MB) is the most common malignant brain tumor in children. MYC genes are frequently amplified and correlate with poor prognosis in MB. BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription. Certain cyclin-dependent kinases (CDKs)