700149P
Avanti
16:0 cholesteryl-d7 ester
Avanti Research™ - A Croda Brand 700149P, powder
Synonym(s):
cholesteryl-d7 palmitate
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About This Item
Empirical Formula (Hill Notation):
C43H69D7O2
CAS Number:
Molecular Weight:
632.11
UNSPSC Code:
41141804
NACRES:
NA.25
Pricing and availability is not currently available.
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (700149P-10mg)
pkg of 1 × 25 mg (700149P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700149P
shipped in
dry ice
storage temp.
−20°C
General description
Cholesteryl palmitate is a cholesteryl ester.[1] 16:0 cholesteryl-d7 ester is the deuterated form of cholesteryl palmitate or 16:0 cholesteryl ester.
Application
16:0 cholesteryl-d7 ester has been used:
- in plasma sample preparation for tandem mass spectrometry analysis (MS/MS)[2]
- as an internal standard in mass spectrometry for quantification of nerve lipids from mice[3]
- as an internal standard in time-of-flight mass spectrometry (TOFMS) for the quantification of serum extracellular vesicles (EVs) lipids[4]
- as an external calibrator and internal spiking standard in tandem mass spectroscopy measurements[5]
- in liposome preparation for retinyl ester hydrolase (REH) and cholesteryl esterase activity assay[6]
Biochem/physiol Actions
Cholesteryl palmitate is associated with atherosclerotic plaque.[1] Deuterated cholesteryl palmitate in used in reconstituting high-density lipoprotein (HDL).[7] An elevated levels of the ratio of cholesteryl oleate to cholesteryl palmitate is implicated with apoptotic cell death in the atherosclerotic lesions.[1]
Packaging
5 mL Amber Glass Screw Cap Vial (700149P-10mg)
5 mL Amber Glass Screw Cap Vial (700149P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Y I Parmar et al.
The Journal of biological chemistry, 258(3), 2000-2004 (1983-02-10)
Reconstituted high density lipoprotein has been prepared by sonication and preparative ultracentrifugation of mixtures containing the apoprotein of high density lipoprotein, egg phosphatidylcholine, cholesteryl oleate, and acyl chain deuterated cholesteryl palmitate in aqueous buffer. The resulting structures have a size
Suming Chen et al.
Journal of circulating biomarkers, 8, 1849454419879848-1849454419879848 (2019-10-22)
There is a wide variety of extracellular vesicles (EVs) that differ in size and cargo composition. EVs isolated from human plasma or serum carry lipid, protein, and RNA cargo that provides insights to the regulation of normal physiological processes, and
Michael S Gardner et al.
Journal of the American Society for Mass Spectrometry, 28(11), 2319-2329 (2017-08-13)
We demonstrate the application of in-source nitrogen collision-induced dissociation (CID) that eliminates the need for ester hydrolysis before simultaneous analysis of esterified cholesterol (EC) and triglycerides (TG) along with free cholesterol (FC) from human serum, using normal phase liquid chromatography
Y Zang et al.
Journal of dairy science, 102(2), 1224-1236 (2018-11-26)
Co-supplementation of methyl donors may lower hepatic lipid content in transition cows. To define the ability of methyl donor supplementation (MDS) to reduce hepatic lipid content and modify the plasma lipidome, 30 multiparous Holstein cows (2.04 ± 0.69 lactations; 689
Maidina Tuohetahuntila et al.
The Journal of biological chemistry, 292(30), 12436-12448 (2017-06-16)
Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters, and retinyl esters (REs). We previously provided evidence for the presence
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