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V1309

Sigma-Aldrich

3,4-Dimethoxybenzylamine

97%

Synonym(s):

Veratrylamine

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About This Item

Linear Formula:
3,4-(CH3O)2C6H3CH2NH2
CAS Number:
5763-61-1
Molecular Weight:
167.21
Beilstein:
511575
EC Number:
227-287-7
MDL number:
MFCD00008116
UNSPSC Code:
12352100
PubChem Substance ID:
24900715
NACRES:
NA.22

Quality Level

100

Assay

97%

refractive index

n20/D 1.556 (lit.)

bp

281-284 °C (lit.)

density

1.109 g/mL at 25 °C (lit.)

SMILES string

COc1ccc(CN)cc1OC

InChI

1S/C9H13NO2/c1-11-8-4-3-7(6-10)5-9(8)12-2/h3-5H,6,10H2,1-2H3

InChI key

DIVNUTGTTIRPQA-UHFFFAOYSA-N

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Application

<ul>
<li><strong>Fluorescence Derivatization for Serotonin Determination:</strong> 3,4-Dimethoxybenzylamine is employed as a sensitive pre-column fluorescence derivatization reagent for measuring serotonin levels in human platelet-poor plasma, enhancing detection sensitivity and specificity (Ishida et al., 1997).</li>
<li><strong>Spectrofluorimetric Analysis of 5-Hydroxyindoles:</strong> This compound serves as a selective fluorogenic reagent for the spectrofluorimetric determination of 5-hydroxyindoles, contributing to accurate and selective analysis techniques in clinical and biochemical studies (Ishida et al., 1991).</li>
</ul>

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Ishida et al.
Journal of chromatography. B, Biomedical sciences and applications, 692(1), 31-36 (1997-04-25)
3,4-Dimethoxybenzylamine is shown to be a highly sensitive pre-column fluorescence derivatization reagent for the determination of serotonin in plasma by high-performance liquid chromatography. The reagent reacts selectively with 5-hydroxyindoles including serotonin in slightly alkaline media in the presence of potassium
J Ishida et al.
The Analyst, 116(3), 301-304 (1991-03-01)
A spectrofluorimetric method has been developed for the sensitive and selective determination of 5-hydroxyindoles; the method is based on the reaction of 5-hydroxyindoles in a weakly alkaline solution (pH 9.0) with aromatic methylamines in the presence of potassium hexacyanoferrate(III) and
A M Feigin et al.
Neuroreport, 6(16), 2134-2136 (1995-11-13)
The irritating, pungent compound, capsaicin (10-20 microM), induces the formation of non-selective ion channels with a wide variety of conductances in protein-free lipid bilayers form from a mixture of zwitterionic phospholipids. The channel-forming activity of capsaicin and four of its

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