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T85308

Sigma-Aldrich

Tris(2-chloroethyl)amine hydrochloride

98%

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About This Item

Linear Formula:
(ClCH2CH2)3N·HCl
CAS Number:
817-09-4
Molecular Weight:
240.99
EC Number:
212-442-3
MDL number:
MFCD00012520
UNSPSC Code:
12352100
PubChem Substance ID:
24900538
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Assay

98%

mp

127-130 °C (lit.)

SMILES string

Cl.ClCCN(CCCl)CCCl

InChI

1S/C6H12Cl3N.ClH/c7-1-4-10(5-2-8)6-3-9;/h1-6H2;1H

InChI key

VEAUDLLZYJVHRI-UHFFFAOYSA-N

Related Categories

Signal Word

Danger

Hazard Statements

H300,H314,H351

Hazard Classifications

Acute Tox. 2 Oral - Carc. 2 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBR0330V
03230MH
01016HE
10729PW
01814BD

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Landmark article Sept. 21, 1946: Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. By Louis S. Goodman, Maxwell M. Wintrobe, William Dameshek, Morton J. Goodman, Alfred Gilman and Margaret T. McLennan.
L S Goodman et al.
JAMA, 251(17), 2255-2261 (1984-05-04)
I Koza et al.
Neoplasma, 36(6), 709-718 (1989-01-01)
Fifty-three patients with advanced Hodgkin's disease, most of them previously treated, received 8 to 16 courses of modified MOPP regimens (nitrogen mustard replaced by trichlormethine in arm A, with addition of vinblastine to the 4-drug regimen in arm B, and
I Sýkora et al.
Neoplasma, 28(5), 565-574 (1981-01-01)
The cytostatic TS-160 (trichloromethine hydrochloride, tris-/2-chloroethyl/amine hydrochloride) was injected subcutaneously into SPF Wistar rats of both sexes. After all doses used, spindle-cell or even polymorphocellular sarcomas developes at the injection sites in both sexes: after the dose of 0.1 mg/kg
N I Ryabchenko et al.
General physiology and biophysics, 10(1), 41-48 (1991-02-01)
The dynamic of chromatin degradation was studied in thymocytes and LS/BL tumour cells. In permeabilised LS/BL cells, the rate of DNA degradation induced by endogenous calcium and magnesium-dependent endonuclease was approx. 25 times slower than in thymocytes. In LS/BL cells
T Hiratsuka
Biochemistry, 27(11), 4110-4114 (1988-05-31)
The chemotherapeutic alkylating reagent tris(2-chloroethyl)amine (TCEA) was used as a trifunctional cross-linking reagent with a cross-linking span of 5 A for myosin subfragment 1 (S-1). When S-1 was incubated with TCEA, all three domains of 20, 26, and 50 kDa
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