935441
Aldehyde functionalized hyaluronic acid
Degree of functionalization ~20%
Synonym(s):
HA-A, Hyaluronic acid, Hyluronic acid aldehyde, Oxidized hyaluronic acid
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About This Item
Linear Formula:
(C14H20NNaO11)n(C14H18NNaO11)m
UNSPSC Code:
12352201
NACRES:
NA.28
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General description
Hyaluronic acid (HA) is an important component of the natural extracellular matrix which plays a vital role in various cellular and tissue functions. It represents some unique properties such as excellent gel-forming properties and chemical modification ability through hydroxyl and carboxyl groups that make them potentially useful for their application in Tissue engineering. Partially oxidized hyaluronate (OHA) containing two highly aldehyde groups in the repeating unit of HA. The dialdehyde groups of OHA are capable of reductive coupling with primary amines and thus can be used in a wide range of chemical modifications of HA as hydrogel for tissue engineering applications and regenerative medicine drug delivery applications
Application
HA is increasingly used for a many biomedical applications because it promotes cell migration, angiogenesis, cell viability, and proliferation. Aldehyde functionalized HA can be used to develop hydrogels for tissue engineering, regenerative medicing, bioprinting, and drug delivery applications.
Features and Benefits
- Coupling capabilities with primary amines
- Biocompatible functionalized natural polymer
- Promotes a variety of cellular and tissue functions
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery
Sonia T, et al.
Pharmaceutics, 11, 407-407 (2019)
Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine
Franca G C, et al.
Polysaccharides, 2, 477-496 (2021)
General Dialdehyde Click Chemistry for Amine Bioconjugation
Elahipanah S, et al.
Bioconjugate Chemistry, 28, 1422-1433 (2017)
Hyaluronic Acid and Controlled Release: A Review
Bayer S I, et al.
Molecules (Basel), 25, 2649-2649 (2020)
Modified hyaluronic acid-based materials for biomedical applications
Tiwari S, et al.
International Journal of Biological Macromolecules, 121, 556-571 (2019)
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