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760773

Sigma-Aldrich

Dibenzocyclooctyne-PEG4-Fluor 545

for Copper-free Click Chemistry

Synonym(s):

Polyethylene glycol, ADIBO-PEG4-TAMRA, DBCO-PEG4-Fluor 545, DBCO-PEG4-TAMRA, DBCO-PEG4-tetramethylrhodamine, TAMRA DBCO

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About This Item

Empirical Formula (Hill Notation):
C54H57N5O10
Molecular Weight:
936.06
UNSPSC Code:
51171641
NACRES:
NA.22

form

solid

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

Related Categories

Application

This azadibenzocyclooctyne-tetramethyl rhodamine (TAMRA) derivative is a versatile fluorescent reagent for labeling azide containing molecules or compounds. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions.This dibenzocyclooctyne will react with azide-functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. Subsequent labeled molecules can be visualized by fluorescence spectroscopy.

Spectral Properties: Abs/Em = 545/567nm

related product

Product No.
Description
Pricing

924083

TAMRA-a-TCO

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Ning, X., et al.
Angewandte Chemie (International Edition in English), 47, 2253-2255 null
Rubino F. A., et al.
Journal of Visualized Experiments, 66, 4246-4246 null
Accelerated Strain-Promoted and Oxidation-Controlled Cyclooctyne-Quinone Cycloaddition for Cell Labeling.
George A, et al.
ChemistrySelect, 2(24), 7117-7122 null
John T Ngo et al.
ACS chemical biology, 7(8), 1326-1330 (2012-06-14)
Transcriptional activity from a specified promoter can provide a useful marker for the physiological state of a cell. Here we introduce a method for selective tagging of proteins made in cells in which specified promoters are active. Tagged proteins can
Michael D Best
Biochemistry, 48(28), 6571-6584 (2009-06-03)
In recent years, a number of bioorthogonal reactions have been developed, exemplified by click chemistry, that enable the efficient formation of a specific product, even within a highly complex chemical environment. While the exquisite selectivity and reliability of these transformations
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Articles

Copper-Free Click Chemistry

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

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