38827

4,4′-Dimethoxytriphenylmethyl chloride

≥97.0% (HPLC)

• Synonym(s): 4,4′-Dimethoxytrityl chloride, Chloro-4,4′-dimethoxytriphenylmethane, DMT, DMT-Cl
• Empirical Formula (Hill Notation): C₂₁H₁₉ClO₂
• CAS Number: 40615-36-9
• Molecular Weight: 338.83
• Beilstein: 2471942
• EC Number: 255-002-6
• MDL number: MFCD00008409
• UNSPSC Code: 12352101
• PubChem Substance ID: 57649867
• NACRES: NA.22

Properties

• Assay: ≥97.0% (HPLC)
• mp: 123-125 °C
• SMILES string: COc1ccc(cc1)C(Cl)(c2ccccc2)c3ccc(OC)cc3
• InChI: 1S/C21H19ClO2/c1-23-19-12-8-17(9-13-19)21(22,16-6-4-3-5-7-16)18-10-14-20(24-2)15-11-18/h3-15H,1-2H3
• InChI key: JBWYRBLDOOOJEU-UHFFFAOYSA-N
• Gene Information: human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358) ; rat ... Htr1a(24473) , Htr2a(29595)

Description

Application

4,4′-Dimethoxytriphenylmethyl chloride (DMTrCl) can be used as a protecting agent:

• For hydroxyl group of nucleosides/nucleotides as its O-(4,4′-dimethoxytrityl)derivative.
• For 1⁰ sulfhydryl group of oligonucleotide analogs as its DMTr thioether.

Other Notes

Useful protecting-group reagent; Removal

Safety Information

• Pictograms: GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H314,H317,H335,H411
• Precautionary Statements: P260 - P271 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 8B - Non-combustible corrosive hazardous materials
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves