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Sigma-Aldrich

Creatine

98%

Synonym(s):

(α-Methylguanido)acetic acid, N-Amidinosarcosine

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About This Item

Linear Formula:
H2NC(=NH)N(CH3)CH2CO2H
CAS Number:
Molecular Weight:
131.13
Beilstein:
907175
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

Assay

98%

SMILES string

CN(CC(O)=O)C(N)=N

InChI

1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

InChI key

CVSVTCORWBXHQV-UHFFFAOYSA-N

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Biochem/physiol Actions

Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP. Approximately 95% of creatine is found in skeletal muscle, primarily as phosphocreatine. Creatine can be acquired through dietary consumption or formed from L-arginine, glycine, and L-methionine in a multi-step reaction that occurs in the kidneys and liver. Creatine is then transported to muscle tissue. Creatine supplementation is used for the enhancement of sports performance, primarily by increasing muscle mass. Creatine is also being investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.

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Creatine--a dispensable metabolite?
Heinrich Taegtmeyer et al.
Circulation research, 112(6), 878-880 (2013-03-16)
Samit Malhotra et al.
Continuum (Minneapolis, Minn.), 19(1 Sleep Disorders), 67-85 (2013-02-13)
This review discusses the various causes of primary hypersomnias with emphasis on clinical recognition, diagnosis, and treatment options. Narcolepsy is probably the most fascinating syndrome causing excessive daytime sleepiness. With increasing understanding of the hypocretin/orexin pathways and the neurotransmitters that
Wilbert A G van der Meijden et al.
Nederlands tijdschrift voor geneeskunde, 157(24), A5944-A5944 (2013-06-14)
Renal function is currently estimated using the Modification of Diet in Renal Disease (MDRD) formula, which is partly based on the serum creatinine level. Patients with impaired renal function are referred to nephrologists in accordance with the Dutch national transmural
Zhe Zhang et al.
Journal of the American Medical Informatics Association : JAMIA, 20(4), 643-651 (2013-02-15)
Intellectual disability is a condition characterized by significant limitations in cognitive abilities and social/behavioral adaptive skills and is an important reason for pediatric, neurologic, and genetic referrals. Approximately 10% of protein-encoding genes on the X chromosome are implicated in intellectual
Gaurav Verma et al.
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To detect regional metabolic differences in amyotrophic lateral sclerosis (ALS) with whole-brain echo-planar spectroscopic imaging. Sixteen patients with ALS (nine men, seven women; mean age, 56.6 years), five persons suspected of having ALS (four men, one woman; mean age, 62.6

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