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About This Item
Linear Formula:
CH3SO2F
CAS Number:
Molecular Weight:
98.10
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Recommended Products
Assay
98%
reaction suitability
reaction type: click chemistry
bp
123-124 °C (lit.)
density
1.427 g/mL at 25 °C (lit.)
SMILES string
CS(F)(=O)=O
InChI
1S/CH3FO2S/c1-5(2,3)4/h1H3
InChI key
KNWQLFOXPQZGPX-UHFFFAOYSA-N
General description
Methanesulfonyl fluoride is an anticholinesterase (antiChEs), used to treat Alzheimer′s disease. It is a thrombin inhibitor.
accessory
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Oral - Skin Corr. 1B
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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D H Malin et al.
Neurobiology of aging, 14(4), 393-395 (1993-07-01)
Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly
A W Snow et al.
Chemical research in toxicology, 1(6), 379-384 (1988-11-01)
The chemical reactivity and physical properties of methanesulfonyl fluoride (MSF) were quantitatively measured for direct comparison with those of isopropyl methylphosphonofluoridate (GB, sarin) and diisopropyl phosphorofluoridate (DFP). The chemistry involved reaction rate constant measurements of MSF hydrolysis and for reactions
Donald E Moss et al.
Journal of Alzheimer's disease : JAD, 55(3), 1285-1294 (2016-11-20)
Irreversible acetylcholinesterase (AChE) inhibition accumulates to high levels in the central nervous system (CNS) because AChE turnover in the brain is much slower than in peripheral tissues. As expected from this CNS selectivity, the irreversible AChE inhibitor methanesulfonyl fluoride (MSF)
M Scuka
Pflugers Archiv : European journal of physiology, 410(4-5), 428-432 (1987-11-01)
In order to study the sensitivity of acetylcholine (ACh) receptors exposed to anticholinesterase drugs, the ionophoretically evoked end-plate currents (e.p.c.i) in frog sartorius muscle were studied. During treatment with prostigmine (PST, 3 microM) or methanesulfonyl fluoride (MSF, 1-2 mM), the
M Shinkai et al.
British journal of pharmacology, 103(1), 1191-1195 (1991-05-01)
1. Contractile responses and acetylcholine release evoked by nicotine in guinea-pig detrusor strips were determined by isotonic transducer and radioimmunoassay, respectively. Nicotine stimulated acetylcholine release and a contractile response in guinea-pig detrusor strips treated with the cholinesterase inhibitor, methanesulphonyl fluoride
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