This product is sourced from rice as stated on the product detail page.
T0452
D-α-Tocotrienol
from rice, ≥75% (GC)
Synonym(s):
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
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About This Item
Empirical Formula (Hill Notation):
C29H44O2
CAS Number:
Molecular Weight:
424.66
UNSPSC Code:
12352205
NACRES:
NA.79
Pricing and availability is not currently available.
Recommended Products
biological source
rice
Quality Level
Assay
≥75% (GC)
form
liquid
color
colorless to brown
mp
30-31 °C
storage temp.
−20°C
SMILES string
O1[C@@](CCc2c1c(c(c(c2C)O)C)C)(CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)C
InChI
1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1
InChI key
RZFHLOLGZPDCHJ-XZXLULOTSA-N
General description
Biochem/physiol Actions
α-Tocotrienol is an effective free radical scavengerand elicits protective functionality during oxidative stress in microsomes.[1] It is a strong antioxidant,[2] which reduces inflammation[4] and is used in cancer treatment.[3] α-tocotrienol supplementation may reduce cholesterol levels in hypercholesterolemia.[3] α-tocotrienol is neuroprotective as it blocks glutamate-induced cell death in neuronal cells.[5]
α-Tocotrienol may be used along with other isoforms to differentiate tocotrienol activities.
Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. α-tocotrienol demonstrates neuroprotective properties by blocking glutamate-induced cell death in neuronal cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Vladimir Gogvadze et al.
International journal of cancer, 127(8), 1823-1832 (2010-01-28)
Release of mitochondrial proteins such as cytochrome c, AIF, Smac/Diablo etc., plays a crucial role in apoptosis induction. A redox-silent analog of vitamin E, alpha-tocopheryl succinate (alpha-TOS), was shown to stimulate cytochrome c release via production of reactive oxygen species
Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling
Packer L, et al.
The Journal of Nutrition, 131(2), 369S-373S (2001)
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice
Qureshi AA, et al.
Lipids in Health and Disease, 9(1), 143-143 (2010)
Tomono Uchida et al.
Lipids, 47(2), 129-139 (2011-11-02)
The aim of this study was to evaluate tissue distribution of vitamin E isoforms such as α- and γ-tocotrienol and γ-tocopherol and interference with their tissue accumulation by α-tocopherol. Rats were fed a diet containing a tocotrienol mixture or γ-tocopherol
Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities
Ramanathan N, et al.
Nutrition & Metabolism, 15(1), 6-6 (2018)
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what is the source of Tocotrienol rice or rice bran oil
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