SML3204
Dapansutrile
≥98% (HPLC)
Synonym(s):
3-(Methylsulfonyl)propanenitrile; 3-(Methylsulfonyl)propionitrile, Dapansutrile
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About This Item
Empirical Formula (Hill Notation):
C4H7NO2S
CAS Number:
Molecular Weight:
133.17
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O=S(C)(CCC#N)=O
InChI key
LQFRYKBDZNPJSW-UHFFFAOYSA-N
Biochem/physiol Actions
Dapansutrile is an orally active, specific and potent inhibitor of NLRP3 inflammasome activation that decreases IL-1β and IL-18 release. Dapansutrile exhibits no effect on NLRC4 and AIM2 inflammasomes activation. It appears that Dapansutrile directly interact with NLRP3. It does not show hematological, or organ toxicities in humans at oral doses up to 1,000 mg/day
orally active, specific and potent inhibitor of NLRP3 inflammasome activation; anti-inflammatory
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse
Journal of Cardiovascular Pharmacology, 73(4), 215-222 (2019)
NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
Arthritis Research & Therapy, 20(1), 169-169 (2018)
OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
Proceedings of the National Academy of Sciences of the USA, 115(7), E1530-E1539 (2018)
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