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SML2662

Sigma-Aldrich

SPA70

≥98% (HPLC)

Synonym(s):

1-(2,5-Dimethoxyphenyl)-4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-5-methyl-1H-12,3-triazole, LC-1

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5 MG
€131.00
25 MG
€423.00

€131.00

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5 MG
€131.00
25 MG
€423.00

About This Item

Empirical Formula (Hill Notation):
C21H25N3O4S
CAS Number:
931314-31-7
Molecular Weight:
415.51
MDL number:
MFCD14774311
UNSPSC Code:
12352200
NACRES:
NA.77

€131.00

Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(c2nn[n](c2C)c3c(ccc(c3)OC)OC)c1ccc(cc1)C(C)(C)C

InChI key

OIOPHIFJQXHPAF-UHFFFAOYSA-N

Biochem/physiol Actions

SPA70 is a cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models. It inhibits hPXR-mediated drug metabolism in in primary human hepatocytes and in mouse models.
cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000154817
0000075410
0000075411
0000072681

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Sergio C Chai et al.
Drug discovery today, 24(3), 906-915 (2019-02-08)
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are ligand-activated nuclear receptors (NRs) that are notorious for their role in drug metabolism, causing unintended drug-drug interactions and decreasing drug efficacy. They control the xenobiotic detoxification system by
Combination of Paclitaxel and PXR Antagonist SPA70 Reverses Paclitaxel-Resistant Non-Small Cell Lung Cancer.
Niu, et al.
Cells, 11 (2022)
Wenwei Lin et al.
Nature communications, 8(1), 741-741 (2017-10-01)
Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70 is a potent and

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