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SML0377

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(S)-FTY720 phosphate

≥94% (HPLC)

Synonym(s):

(+)-(S)-FTY 720 phosphate, (2S)-2-Amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol), (S)-FTY 720P

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About This Item

Empirical Formula (Hill Notation):
C19H34NO5P
CAS Number:
402616-26-6
Molecular Weight:
387.45
UNSPSC Code:
12352211

Assay

≥94% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 0.3 mg/mL, clear (warmed)

storage temp.

−20°C

Biochem/physiol Actions

FTY20 phosphate (FTY720-P) is a sphingosine 1-phosphate (S1PR) receptor agonist and immunomodulatory agent, the active metabolite of FTY720. FTY720P acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors and Lysophospholipid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Nitai C Hait et al.
Nature neuroscience, 17(7), 971-980 (2014-05-27)
FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is

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