SAB4504720

Anti-phospho-p16-INK4a (pSer¹⁵²) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): MTS1, Multiple tumor suppressor 1, p14ARF
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 17 kDa
• species reactivity: human, rat, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:1000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P42771
• UniProt accession no.: P42771
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer152)
• Gene Information: human ... CDKN2A(1029)

Description

General description

p16INK4A (cyclin-dependent kinase inhibitor 2A isoform) and p14ARF (cyclin-dependent kinase inhibitor 2A) are encoded by the CDKN2A (cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor) gene. p16INK4A is a low molecular weight protein. This gene is mapped to human chromosome 9p21.

Immunogen

The antiserum was produced against synthesized peptide derived from human p16-INK4a around the phosphorylation site of Ser152.

Immunogen Range: 107-156

Biochem/physiol Actions

p16INK4A (cyclin-dependent kinase inhibitor 2A isoform) serves as a tumor suppressor and it negatively modulates cell growth by arresting cells in the G1 phase. Mutations in the CDKN2A (cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor) gene is the main reason of inherited susceptibility to melanoma.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable