SAB1300251

Anti-CCL19 (N-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000
• NCBI accession no.: NP_006265
• UniProt accession no.: Q99731
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CCL19(6363)

Description

General description

CCL19 (C-C motif chemokine ligand 19) gene is mapped in human chromosome 9p13.3. CCL19 is constantly expressed in secondary lymphoid tissue.

The gene for CCL19 is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL19 may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.

Immunogen

CCL19 (NP_006265, 11-41)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CCL19.

Biochem/physiol Actions

CCL19 (C-C motif chemokine ligand 19) is an homeostatic chemokine, involved in adaptive immune system. CCL19 recruits monocytes, macrophages, antigen presenting dendritic cells and naïve T-cells to secondary lymphoid organs by activation of CCR7 (C-C motif chemokine receptor 7). It controls cell migration in inflammation reaction and dysregulated angiogenesis in many types of diseases. CCL19 is upregulated in human atherosclerotic lesions. CCL19 is involved in the development of various inflammatory disorders such as asthma, atherosclerosis and rheumatoid arthritis. CCL19 might also be associated with the pathogenesis of rickettsiae infection.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable