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Key Documents

P6337

Sigma-Aldrich

Protein Tyrosine Phosphatase Substrate

≥97% (HPLC)

Synonym(s):

Insulin Receptor fragment 1142-1153 human, PTPase substrate

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About This Item

Empirical Formula (Hill Notation):
C72H107N19O24
CAS Number:
Molecular Weight:
1622.73
MDL number:
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

storage temp.

−20°C

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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T O'Hare et al.
The Journal of biological chemistry, 264(1), 602-610 (1989-01-05)
We are interested in developing methods to rigorously characterize the intrinsic enzymatic activity of the insulin receptor. We have previously shown that the intact, kinase active form of the receptor can be separated from inactive forms isolated from human placenta.
M J King et al.
FEBS letters, 237(1-2), 137-140 (1988-09-12)
Synthetic peptide 1142-1153 of the insulin receptor was phosphorylated on tyrosine by the insulin receptor and found to be a potent substrate for dephosphorylation by rat liver particulate and soluble phosphotyrosyl protein phosphatases. Apparent Km values were approximately 5 microM.
L Stadtmauer et al.
The Journal of biological chemistry, 261(21), 10000-10005 (1986-07-25)
Three peptides were synthesized corresponding to potential autophosphorylation sites of the beta subunit of the human insulin receptor. These were peptide 1150 corresponding to amino acids 1142-1153 of the pro-receptor, peptide 960 corresponding to amino acids 952-961 of the proreceptor
Bannwarth, W., and Kitas, E.A.
Helvetica Chimica Acta, 75, 707-707 (1992)

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