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L9250

Sigma-Aldrich

Leu-Ala hydrate

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Synonym(s):

L-Leucyl-L-alanine hydrate

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)CONHCH(CH3)COOH · xH2O
CAS Number:
7298-84-2
Molecular Weight:
202.25 (anhydrous basis)
Beilstein:
1726165
MDL number:
MFCD00149112
UNSPSC Code:
12352209
PubChem Substance ID:
24896519
NACRES:
NA.26

Assay

≥98% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

2-8°C

SMILES string

O.CC(C)C[C@H](N)C(=O)N[C@@H](C)C(O)=O

InChI

1S/C9H18N2O3.H2O/c1-5(2)4-7(10)8(12)11-6(3)9(13)14;/h5-7H,4,10H2,1-3H3,(H,11,12)(H,13,14);1H2/t6-,7-;/m0./s1

InChI key

FTDFAGANYJVHDA-LEUCUCNGSA-N

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General description

Leucylalanine (Leu-Ala) is useful to produce non-electrolytic triorganotin (IV) derivatives (R3Sn(HL)) to study the models of metal-protein interactions.

Application

Leu-Ala hydrate has been used as a substrate in Tris-hydrochloride (HCl) buffer to analyze the leucine-alanine peptidase (LAP) activity in larvae.
Leucylalanine (Leu-Ala) is use to make non-electrolytic triorganotin(IV) derivatives (general formulae R3Sn(HL)) to study models of metal-protein interactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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New triorganotin (IV) derivatives of dipeptides as models for metal-protein interactions: synthesis, structural characterization and biological studies.
Nath M, Pokharia S, Eng G, Song X, Kumar A.
Spectrochimica Acta Part A: Molecular Spectroscopy, 63, 66-75 (2006)
David S Milner et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(12), 5613-5622 (2019-03-08)
Many microbes acquire metabolites in a "feeding" process where complex polymers are broken down in the environment to their subunits. The subsequent uptake of soluble metabolites by a cell, sometimes called osmotrophy, is facilitated by transporter proteins. As such, the
Arun K Ghosh et al.
Bioorganic & medicinal chemistry letters, 18(3), 1031-1036 (2008-01-09)
Structure-based design, synthesis, and biological evaluation of a series of peptidomimetic beta-secretase inhibitors incorporating hydroxyethylamine isosteres are described. We have identified inhibitor 24 which has shown exceedingly potent activity in memapsin 2 enzyme inhibitory (K(i) 1.8 nM) and cellular (IC(50)=1
Arun K Ghosh et al.
Journal of medicinal chemistry, 50(10), 2399-2407 (2007-04-17)
Structure-based design and synthesis of a number of potent and selective memapsin 2 inhibitors are described. These inhibitors were designed based upon the X-ray structure of memapsin 2-bound inhibitor 3 that incorporates methylsulfonyl alanine as the P2-ligand and a substituted
L P Biały et al.
Folia histochemica et cytobiologica, 40(2), 135-136 (2002-06-12)
We have used the dipeptide Leu-Ala in an attempt to prevent the formation of ubiquitin-protein conjugates in U937 cells by inhibition of cellular E3 enzymes (ubiquitin ligases). Proteasome inhibitors induce the formation of perinuclear aggregates of ubiquitinated proteins and proteasomes
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