K3018
PAK3, active, GST tagged from mouse
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
Pak65alpha, Pak65beta, Stk4
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
221-298 nmol/min·mg
mol wt
~89 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... Pak3(18481)
Biochem/physiol Actions
PAK3 (p21 protein (Cdc42/Rac)-activated kinase 3) is a member of the family of serine/threonine protein kinases that serve as targets for the small GTPases, Cdc42 (cell division cycle 42) and RAC (AKT1, v-akt murine thymoma viral oncogene homolog 1). The PAK family of proteins has been implicated in a wide range of biological activities and are involved in the control of gene transcription, cell morphology, motility and cell death. A point mutation in PAK3 gene has been linked to nonsyndromic X-linked mental retardation. PAK3 is strongly expressed in brain, mainly in the hippocampus.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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T Bienvenu et al.
American journal of medical genetics, 93(4), 294-298 (2000-08-18)
X-linked mental retardation is a very common condition that affects approximately 1 in 600 males. Despite recent progress, in most cases the molecular defects underlying this disorder remain unknown. Recently, a study using the candidate gene approach demonstrated the presence
E Manser et al.
The Journal of biological chemistry, 270(42), 25070-25078 (1995-10-20)
A number of "target" proteins for the Rho family of small GTP-binding proteins have now been identified, including the protein kinases ACK and p65PAK (Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., and Lim, L. (1994) Nature 367, 40-46). The
Bernadett Boda et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(48), 10816-10825 (2004-12-03)
Mutations of the gene coding for PAK3 (p21-activated kinase 3) are associated with X-linked, nonsyndromic forms of mental retardation (MRX) in which the only distinctive clinical feature is the cognitive deficit. The mechanisms through which PAK3 mutation produces the mental
K M Allen et al.
Nature genetics, 20(1), 25-30 (1998-09-10)
Nonsyndromic X-linked mental retardation (MRX) syndromes are clinically homogeneous but genetically heterogeneous disorders, whose genetic bases are largely unknown. Affected individuals in a multiplex pedigree with MRX (MRX30), previously mapped to Xq22, show a point mutation in the PAK3 (p21-activated
Zahara M Jaffer et al.
The international journal of biochemistry & cell biology, 34(7), 713-717 (2002-04-16)
The p21-activated kinases (Paks) are serine/threonine protein kinases that bind to and, in some cases, are stimulated by activated forms of the small GTPases, Cdc42 and Rac. With the recent discovery of several novel isoforms, Paks are now categorized into
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