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D7625

Sigma-Aldrich

2′-Deoxycytidine 5′-monophosphate sodium salt

Sigma Grade, ≥98%

Synonym(s):

Deoxycytidylic acid, dCMP

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100 MG
€85.50
1 G
€496.00

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100 MG
€85.50
1 G
€496.00

About This Item

Linear Formula:
C9H12N3O7PNa2
CAS Number:
13085-50-2
Molecular Weight:
351.16
EC Number:
235-995-2
MDL number:
MFCD00069774
UNSPSC Code:
41106305
PubChem Substance ID:
24894142
NACRES:
NA.51

€85.50

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biological source

microbial (fermentation)

Quality Level

200

grade

Sigma Grade

Assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)N(C=C1)C2CC(O)C(COP(O)(O)=O)O2

InChI

1S/C9H14N3O7P.Na.H/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17;;/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17);;

InChI key

BLEUYVBRJBDVEH-UHFFFAOYSA-N

Application

2′-Deoxycytidine 5′-monophosphate sodium salt has been used:
  • in nucleoside stability studies in human renal cell carcinoma (RCC) cell line SN12C[1]
  • in the cell proliferation studies of human intestinal Caco-2 cell line[2] and peripheral blood mononuclear cells (PBMCs)[3]
  • as a ligand in dsDNA activation-induced cytidine deaminase crystallization[4]
2′-Deoxycytidine 5-monophosphate (dCMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form dCDP which upon phosphorylation to dCTP supports DNA and RNA biosynthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000382415
0000354134
0000382415
SLCQ7248
0000296784

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CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
Zauri M, et al.
Nature, 524(7563), 114-114 (2015)
Rafael Andrade Caceres et al.
Journal of molecular modeling, 14(5), 427-434 (2008-03-18)
Bacterial cytidylate kinase or cytidine monophosphate kinase (CMP kinase) catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates. In eukaryotes, CMP/UMP kinase catalyses the conversion of UMP and CMP to, respectively, UDP and
AID recognizes structured DNA for class switch recombination
Qiao Q, et al.
Molecular Cell, 67(3), 361-373 (2017)
Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion
Holen E, et al.
Nutrition, 22(1), 90-96 (2006)
Dietary nucleotides and intestinal cell lines: I. Modulation of growth
Holen E and Jonsson R
Nutrition Research (New York, N.Y.), 24(3), 197-207 (2004)
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