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C7519

Sigma-Aldrich

Choline bicarbonate

~80% in H2O

Synonym(s):

2-Hydroxyethyl)trimethylammonium bicarbonate

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About This Item

Linear Formula:
C5H14NO · HCO3
CAS Number:
78-73-9
Molecular Weight:
165.19
MDL number:
MFCD00031689
UNSPSC Code:
50501514
PubChem Substance ID:
24892967
NACRES:
NA.25

form

liquid

concentration

~80% in H2O

density

1.17 g/mL at 25 °C (lit.)

lipid type

phospholipids

storage temp.

2-8°C

SMILES string

OC([O-])=O.C[N+](C)(C)CCO

InChI

1S/C5H14NO.CH2O3/c1-6(2,3)4-5-7;2-1(3)4/h7H,4-5H2,1-3H3;(H2,2,3,4)/q+1;/p-1

InChI key

DQKGOGJIOHUEGK-UHFFFAOYSA-M

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Application

Choline, a water soluble essential nutrient, is used by the body to make phosphatidylcholine phosphatides and neurotransmitter such as acetylcholine. Choline is used to study a wide range of biological processes from stem cell development to neurological disease studies. Also, An alkaline intermediate useful for preparing salts.

Biochem/physiol Actions

Acyl group acceptor

Substrates

Choline acetyltransferase substrate

Other Notes

Note: The bicarbonate converts to the carbonate with release of CO2 on aging.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Louisa G Sylvia et al.
Psychotherapy and psychosomatics, 82(1), 10-19 (2012-11-14)
Pharmacotherapy is the first line of treatment for bipolar disorder, but many patients continue to experience persistent subthreshold symptoms. Alternative adjunct treatments, including nutritional therapies, may have the potential to alleviate residual symptoms and improve the outcomes of standard pharmacotherapy.
Ludmilla R Jorge et al.
Frontiers in pharmacology, 11, 243-243 (2020-05-12)
In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized
Vimisha Dharamdasani et al.
Journal of controlled release : official journal of the Controlled Release Society, 323, 475-482 (2020-04-28)
Skin diseases such as lupus, cancer, psoriasis, and hyperhidrosis can potentially be treated effectively by suppressing allele-specific genes using small interfering RNA (siRNA). Injections of siRNA into skin, though effective, are painful and cover small surface areas and thus are
Mohit J Mehta et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 25(5), 1269-1274 (2018-11-07)
Significant research is currently underway to develop environmentally friendly UV-shielding materials. Herein, we have constructed choline citrate (a biobased ionic liquid, IL) stabilized homogeneous gelatin-lignin UV-shielding films with excellent antimicrobial and mechanical properties. The synthesis procedure of the films is
Eden E L Tanner et al.
Journal of controlled release : official journal of the Controlled Release Society, 286, 137-144 (2018-07-22)
Transdermal delivery of pharmaceuticals using ionic liquids and deep eutectic solvents (DES) has attracted significant interest due to the inherent tunability of the molecules and their capacity to transport large molecules across the skin. Several key properties of DESs including
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