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01580590

Ginsenoside Rf

primary reference standard

Synonym(s):

(3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside, Panaxoside Rf

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About This Item

Empirical Formula (Hill Notation):
C42H72O14
CAS Number:
Molecular Weight:
801.01
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

primary reference standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

application(s)

food and beverages

storage temp.

−20°C

SMILES string

[H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]2([H])O[C@H]3C[C@]4(C)[C@]([H])(C[C@@H](O)[C@]5([H])[C@]([H])(CC[C@@]45C)[C@@](C)(O)CC\C=C(/C)C)[C@@]6(C)CC[C@H](O)C(C)(C)[C@]36[H]

InChI

1S/C42H72O14/c1-20(2)10-9-13-42(8,52)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-37-34(32(50)30(48)25(19-44)55-37)56-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+,26+,27-,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,39+,40+,41+,42-/m0/s1

InChI key

UZIOUZHBUYLDHW-XUBRWZAZSA-N

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General description

Ginsenoside is a steroid-like molecular component having gonane steroid nucleus along with different sugar moieties attached to them found in the roots of Panax ginseng. Ginsenoside Rf, a variety of ginseng saponins with attached sugars moieties which inhibits the Ca2+ channels present in primary sensory neurons.
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

It may be used as reference standard in HPLC-MS/MS analysis of human plasma to determine Ginsenosides from herbal products containing Panax ginseng and Panax quinquefolius.

Other Notes

This compound is commonly found in plants of the genus: panax

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Customers Also Viewed

Noel S Quiming et al.
Analytical and bioanalytical chemistry, 389(5), 1477-1488 (2007-09-07)
The influences of the organic component of the mobile phase and the column temperature on the retention of ginsenosides on a poly(vinyl alcohol) (PVA) bonded stationary phase operated under hydrophilic interaction chromatographic mode were investigated. The retention of the ginsenosides
Cuk-seong Kim et al.
Acta pharmacologica Sinica, 26(5), 551-558 (2005-04-22)
To examine the effects of ginseng saponins on the heterologously expressed human ether-a-go-go related gene (HERG) that encodes the rapid component of the delayed rectifier K+ channel. A two-electrode voltage clamp technique was used. HERG currents were recorded in Xenopus
The antimetastatic and immunomodulating activities of ginseng minor glycosides.
A M Popov et al.
Doklady. Biochemistry and biophysics, 380, 309-312 (2001-12-01)
Sunoh Kim et al.
Biochemical and biophysical research communications, 365(3), 399-405 (2007-11-21)
In the present study, we have examined any possible involvement of L-type Ca(2+) channels in ginseng-mediated neuroprotective actions. Exposure to a 50mM KCl (high-K) produced neuronal cell death, which was blocked by a selective L-type Ca(2+) channel blocker in cultured
Seok Choi et al.
Molecular pharmacology, 61(4), 928-935 (2002-03-20)
We have shown that ginsenoside Rf (Rf) regulates voltage-dependent Ca(2+) channels through pertussis toxin (PTX)-sensitive G proteins in rat sensory neurons. These results suggest that Rf can act through a novel G protein-linked receptor in the nervous system. In the

Articles

Optimize HPLC method for ginsenoside separation using a mixture, applying it to American Ginseng root, with conditions and chromatograms shown.

In this article we present several HPTLC applications and analytical standards for ginsenosides.

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