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Key Documents

28-4840

Sigma-Aldrich

Sorbitan monooleate

SAJ first grade

Synonym(s):

Span® 80

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About This Item

Empirical Formula (Hill Notation):
C24H44O6
CAS Number:
Molecular Weight:
428.60
Beilstein:
8172514
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:

grade:
SAJ first grade

grade

SAJ first grade

form

liquid

availability

available only in Japan

refractive index

n20/D 1.48 (lit.)

density

0.986 g/mL at 25 °C (lit.)

SMILES string

[H][C@@](O)(COC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

InChI key

NWGKJDSIEKMTRX-AAZCQSIUSA-N

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Legal Information

Span is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

485.6 °F

Flash Point(C)

252 °C


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    Faiyaz Shakeel et al.
    Drug development and industrial pharmacy, 40(9), 1240-1245 (2013-07-11)
    Abstract For the development of an effective self-nanoemulsifying drug delivery system (SNEDDS) of poorly soluble drugs, the knowledge of the solubility in its oil phase and SNEDDS are one of the most important factors to avoid possibility of drug to
    Geneviève LeBel et al.
    Applied and environmental microbiology, 80(17), 5484-5492 (2014-06-29)
    Streptococcus suis serotype 2 is known to cause severe infections (meningitis, endocarditis, and septicemia) in pigs and is considered an emerging zoonotic agent. Antibiotics have long been used in the swine industry for disease treatment/prevention and growth promoters. This pattern
    Hoang Hirschberg et al.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(1-2), 1-7 (2012-02-15)
    In the search for an optimal approach for the transcutaneous immunization (TCI) of hepatitis B surface antigen (HBsAg), two vesicle formulations, L595 vesicles (composed of sucrose-laurate ester and octaoxyethylene-laurate ester) and sPC vesicles (composed of soybean-phosphatidylcholine and Span-80) were prepared
    Chenguang Zhou et al.
    Molecular pharmaceutics, 9(2), 201-210 (2011-12-14)
    Nonionic surfactant vesicles, or SPANosomes (SPs), comprised of cationic lipid and sorbitan monooleate (Span 80) were synthesized and evaluated as small interfering RNA (siRNA) vectors. The SPs had a mean diameter of less than 100 nm and exhibited excellent colloidal
    Xiazhong Ren et al.
    International journal of pharmaceutics, 431(1-2), 130-137 (2012-05-03)
    This study is the first to investigate and demonstrate the potential of microemulsions (MEs) for sustained release parenteral drug delivery, due to phase transition behavior in aqueous environments. Phase diagrams were constructed with Miglyol 812N oil and a blend of

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