HND3MAG-39K

MILLIPLEX^® Human Neurological Disorders Magnetic Bead Panel 3 - Neuroscience Multiplex Assay

The analytes available for this multiplex kit are: AGT, Contactin-1, Fetuin A, Kallikrein-6, OPN, sSOD1, sSOD2

• UNSPSC Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

Properties

• Quality Level: 200
• species reactivity: human
• manufacturer/tradename: Milliplex^®
• assay range: accuracy: 69-92%; (Cerebrospinal fluid (CSF)); accuracy: 71-107%; (Serum); standard curve range: 0.03-25 ng/mL; (SOD2); standard curve range: 0.04-30 ng/mL; (Kallikrein-6); standard curve range: 0.04-30 ng/mL; (SOD1); standard curve range: 0.08-60 ng/mL; (Contactin-1); standard curve range: 0.14-100 ng/mL; (Osteopontin (OPN)); standard curve range: 1.37-1,000 ng/mL; (AGT); standard curve range: 4.12-3,000 ng/mL; (Fetuin A)
• technique(s): multiplexing: suitable
• detection method: fluorometric (Luminex xMAP)
• shipped in: wet ice

Description

General description

Neurological disorders are diseases of the brain, spinal cord, and nerves. There are more than 600 diseases of the nervous system, such as Multiple sclerosis (MS), Alzheimer′s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson′s disease (PD), and stroke as well as frontotemporal dementia and many others. Identification of biomarkers for these neurological disorders allows scientists to identify early signs of neurological damage, track disease progression, and monitor efficacy of therapeutic treatment. The MILLIPLEX^® 7-plex Human Neurological Disorders Bead Panel 3 is designed for the simultaneous measurement of multiple biomarkers in human cerebrospinal fluid (CSF), plasma, and serum using the Luminex^® xMAP^® instrument platform. The kit contains enough material to analyze 38 samples in duplicate, including the standard curve and two quality controls.

NOTE: For serum and plasma samples Fetuin A requires a higher (1:4000) dilution and therefore must be assayed alone as a singleplex. For serum or plasma samples all analytes, except Fetuin A, require a 1:50 dilution and may be assayed together as a multiplex.

The MILLIPLEX^® Human Neurological Disorders Bead Panel 3 (Cat. No. HND3MAG-39K) is to be used for the simultaneous quantification of the following 7 analytes in any combination in CSF, serum or plasma samples: Angiotensinogen (AGT), Contactin-1, Fetuin A, Kallikrein-6, Osteopontin (OPN), Soluble Superoxide Dismutase 1 (SOD1), Soluble Superoxide Dismutase 2 (SOD2).

NOTE: For serum and plasma samples Fetuin A requires a higher (1:4000) dilution and therefore must be assayed alone as a singleplex. For serum or plasma samples all analytes, except Fetuin A, require a 1:50 dilution and may be assayed together as a multiplex.

Panel Type: Neuroscience

Specificity

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Application

• Analytes: Angiotensinogen (AGT), Contactin-1, Fetuin A, Kallikrein-6, Osteopontin (OPN), Soluble Superoxide Dismutase 1 (SOD1), Soluble Superoxide Dismutase 2 (SOD2)
• Recommended Sample type: CSF, serum, and plasma
• Recommended Sample dilution: 1:100 for CSF, 1:50 for serum and plasma for all analytes except Fetuin A, 1:4000 for serum and plasma for Fetuin A
• NOTE: Fetuin A cannot be assayed along with other analytes in serum/plasma samples. Fetuin A should be diluted 1:4000 in the kit Assay Buffer and analyzed as a singleplex for serum and plasma samples
• Assay Run Time: One day or Overnight
• Research Category: Neuroscience

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Packaging

Everything you need in a single kit.

Storage and Stability

Recommended storage for kit components is 2 - 8°C.

Other Notes

Sensitivity: Refer to kit protocol for sensitivities of individual biomarkers.

Legal Information

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS08,GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H302 + H312 + H332,H317,H318,H373,H411
• Precautionary Statements: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• Target Organs: Respiratory Tract
• Storage Class Code: 10 - Combustible liquids