444247

MMP Inhibitor II

The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): MMP Inhibitor II, N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
• Empirical Formula (Hill Notation): C₂₁H₂₇N₃O₈S₂
• CAS Number: 203915-59-7
• Molecular Weight: 513.58
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C21H27N3O8S2/c1-21(2)13-23(33(27,28)17-9-5-15(31-3)6-10-17)20(19(25)22-26)24(14-21)34(29,30)18-11-7-16(32-4)8-12-18/h5-12,20,26H,13-14H2,1-4H3,(H,22,25)
• InChI key: MCSWSPNUKWMZHM-UHFFFAOYSA-N

Description

General description

A potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

A potent, reversible, broad-range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 24 nM, 18.4 nM, 30 nM, 2.7 nM, against MMP-1, MMP-3, MMp-7, and MMP-9, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Requires vigorous vortexing for 60 seconds to completely solubilize the product.

Other Notes

Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable