A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells.
A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.
Biochem/physiol Actions
Primary Target soluble guanylate cyclase
Target IC50: 2 µM against soluble guanylate cyclase
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.
Other Notes
Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855. Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361. Beasley, D., et al. 1991. J. Clin. Invest. 87, 602. Pandol, S.J., et al. 1990. J. Biol. Chem.265, 12846. Light, D.B., et al. 1989. Science 243, 383. Mulsch, A. 1988. J. Pharmacol. Exp. Ther.247, 283. Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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