219011

Caspase Inhibitor VI

InSolution, ≥95%

• Synonym(s): InSolution Caspase Inhibitor VI
• Empirical Formula (Hill Notation): C₂₁H₂₈FN₃O₇
• Molecular Weight: 453.46
• UNSPSC Code: 12352200
• NACRES: NA.54

Properties

• Quality Level: 100
• Assay: ≥95% (TLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated; protect from light
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A cell-permeable, irreversible, and general caspase inhibitor. Also reported to inhibit Peptide: N-glycanase (PNGase) in vitro and in vivo. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
general caspase inhibitor

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Sequence

Z-Val-Ala-Asp-CH₂F*

Physical form

A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI (Cat. No. 219007) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.

Other Notes

Misaghi, S., et al. 2004. Chem. Biol.11, 1677.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 188.6 °F
• Flash Point(C): 87 °C